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Tytuł:
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5NosoAE: a web server for nosocomial bacterial antibiogram investigation and epidemiology survey.
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Autorzy:
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Chen CC; Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung, Taiwan.
Liu YY; Department of Public Health, China Medical University, Taichung, Taiwan.
Yang YC; Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung, Taiwan.
Hsu CY; Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung, Taiwan.
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Źródło:
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Nucleic acids research [Nucleic Acids Res] 2022 Jul 05; Vol. 50 (W1), pp. W21-W28.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: 1992- : Oxford : Oxford University Press
Original Publication: London, Information Retrieval ltd.
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MeSH Terms:
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Anti-Bacterial Agents*/pharmacology
Bacteria*/drug effects
Bacteria*/genetics
Bacteria*/pathogenicity
Cross Infection*/epidemiology
Cross Infection*/microbiology
Drug Resistance, Bacterial*/genetics
Microbial Sensitivity Tests*
Internet*
Software*
Bacterial Infections*/epidemiology
Bacterial Infections*/microbiology
Humans ; Phylogeny ; Genome, Bacterial/genetics ; Spatio-Temporal Analysis ; Data Visualization
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Substance Nomenclature:
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0 (Anti-Bacterial Agents)
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Entry Date(s):
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Date Created: 20220531 Date Completed: 20230407 Latest Revision: 20230412
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Update Code:
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20240104
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PubMed Central ID:
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PMC9252726
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DOI:
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10.1093/nar/gkac423
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PMID:
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35639518
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5NosoAE is a webserver that can be used for nosocomial bacterial analysis including the identification of similar strains based on antimicrobial resistance profiles (antibiogram) and the spatiotemporal distribution visualization and phylogenetic analysis of identified strains with similar antibiograms. The extensive use of antibiotics has caused many pathogenic bacteria to develop multiple drug resistance, resulting in clinical infection treatment challenges and posing a major threat to global public health. Relevant studies have investigated the key determinants of antimicrobial resistance in the whole-genome sequence of bacteria. However, a web server is currently not available for performing large-scale strain searches according to antimicrobial resistance profiles and visualizing epidemiological information including the spatiotemporal distribution, antibiogram heatmap, and phylogeny of identified strains. Here, we implemented these functions in the new server, referred to as 5NosoAE. This server accepts the genome sequence file in the FASTA format of five nosocomial bacteria, namely Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, Enterococcus faecium and Staphylococcus aureus for query. All visualizations are implemented in JavaScript and PHP. This server will be useful for physicians and epidemiologists involved in research on infectious disease. The 5NosoAE platform is available at https://nosoae.imst.nsysu.edu.tw.
(© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.)
