-
Tytuł:
-
The Role of Toll-like Receptors in Esophageal Cancer.
-
Autorzy:
-
Davakis S; Upper Gastrointestinal and General Surgery Unit, First Department of Surgery, 'Laikon' General Hospital, National and Kapodistrian University of Athens, Athens, Greece; .
Kapelouzou A; Clinical, Experimental Surgery & Translational Research, Biomedical Research Foundation Academy of Athens, Athens, Greece.
Liakakos T; Upper Gastrointestinal and General Surgery Unit, First Department of Surgery, 'Laikon' General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Mpoura M; Upper Gastrointestinal and General Surgery Unit, First Department of Surgery, 'Laikon' General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Stergiou D; Upper Gastrointestinal and General Surgery Unit, First Department of Surgery, 'Laikon' General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Sakellariou S; First Department of Pathology, 'Laikon' General Hospital, University of Athens, Medical School, Athens, Greece.
Charalabopoulos A; Upper Gastrointestinal and General Surgery Unit, First Department of Surgery, 'Laikon' General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
-
Źródło:
-
Anticancer research [Anticancer Res] 2022 Jun; Vol. 42 (6), pp. 2813-2818.
-
Typ publikacji:
-
Journal Article; Review
-
Język:
-
English
-
Imprint Name(s):
-
Publication: Attiki, Greece : International Institute of Anticancer Research
Original Publication: Athens, Greece : Potamitis Press
-
MeSH Terms:
-
Esophageal Neoplasms*/pathology
Esophageal Squamous Cell Carcinoma*/pathology
Gastroesophageal Reflux*
Toll-Like Receptors*/metabolism
Humans ; Toll-Like Receptor 3/metabolism ; Toll-Like Receptor 4/metabolism ; Toll-Like Receptor 9/metabolism
-
Contributed Indexing:
-
Keywords: Esophageal cancer; Toll-like receptors; adenocarcinoma; microbiome; review; squamous cell carcinoma
-
Substance Nomenclature:
-
0 (Toll-Like Receptor 3)
0 (Toll-Like Receptor 4)
0 (Toll-Like Receptor 9)
0 (Toll-Like Receptors)
-
Entry Date(s):
-
Date Created: 20220531 Date Completed: 20220602 Latest Revision: 20220608
-
Update Code:
-
20240104
-
DOI:
-
10.21873/anticanres.15762
-
PMID:
-
35641301
-
Esophageal adenocarcinoma (AC) develops through Barrett's esophagus (BE) and columnar dysplasia, preceded by gastro-esophageal reflux disease (GERD). Incidence of esophageal squamous cell carcinoma (SCC) is increased with tobacco smoking and alcohol abuse. Toll-like receptors (TLRs) can act as prognostic factors and potential therapeutic targets of esophageal cancer. TLRs, an important family of pattern recognition receptors, allow immune cells to recognize pathogens triggering inflammation. TLR-signaling pathway activates signaling-elements, regulating inflammatory response, possibly correlating to carcinogenesis. In the normal esophagus, TLRs recognize molecular patterns on microorganisms and inflammatory response produced by tissue-damage. TLR3, TLR4, TLR5, and TLR9 are expressed at increasing levels from GERD to AC. TLR4 is a mediator of proliferation in AC, while TRL1 and TLR4 over-expression in AC is related to poor prognosis and metastasis. Additionally, TLR3, TLR4, and TLR9 expression in SCC has been associated with lymphatic metastasis, whereas increased expression of TLR7 and TLR9 has been also associated with advanced disease. It seems that TLR expression can indicate esophageal metaplasia, dysplasia, and cancer. Herein, we aimed to present all available data regarding the relation of TLRs and esophageal cancer. They may represent significant and valuable diagnostic or prognostic factors for esophageal cancer.
(Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
