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Tytuł:
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Review of recent insights in the measurement and modelling of the B-term dispersion and related mass transfer properties in liquid chromatography.
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Autorzy:
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Desmet G; Vrije Universiteit Brussel, Department of Chemical Engineering, Pleinlaan 2, 1050, Brussel, Belgium. Electronic address: .
Broeckhoven K; Vrije Universiteit Brussel, Department of Chemical Engineering, Pleinlaan 2, 1050, Brussel, Belgium.
Deridder S; KU Leuven, Department of Chemical Engineering, Process and Environmental Technology Lab, J. De Nayerlaan 5, 2860, Sint-Katelijne-Waver, Belgium.
Cabooter D; KU Leuven, Department for Pharmaceutical and Pharmacological Sciences, Pharmaceutical Analysis, Herestraat 49, Leuven, Belgium.
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Źródło:
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Analytica chimica acta [Anal Chim Acta] 2022 Jun 29; Vol. 1214, pp. 339955. Date of Electronic Publication: 2022 May 23.
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Typ publikacji:
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Journal Article; Review
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Język:
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English
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Imprint Name(s):
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Publication: Amsterdam : Elsevier
Original Publication: Amsterdam.
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MeSH Terms:
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Models, Chemical*
Chromatography, Liquid ; Diffusion
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Entry Date(s):
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Date Created: 20220601 Date Completed: 20220603 Latest Revision: 20220603
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Update Code:
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20240105
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DOI:
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10.1016/j.aca.2022.339955
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PMID:
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35649640
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In this contribution, we review the recent literature relating to the measurement and modelling of all diffusion-dominated processes contributing to the efficiency of a chromatographic column. In first instance, this involves the measurement and modelling of the overall effective diffusion coefficient D eff (determining the so-called B-term band broadening). The latter manifests itself most clearly during a so-called peak parking experiment. Using effective medium theory modelling, the measured D eff -value can subsequently be decomposed into its constituent contributions, of which the intra-particle or the mesoporous zone and the surface diffusion coefficient are the most important ones. As an accurate estimation of the diffusion processes also allows computing the C-term plate height contribution terms, the review ends with some recent insights obtained when using the established B- and C-term contributions to compute the degree of eddy-dispersion in contemporary packed bed columns.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
