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Tytuł:
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Cytokine aerobics: Oxidation controls cytokine dynamics and function.
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Autorzy:
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Brandhofer M; Division of Vascular Biology, Institute for Stroke and Dementia Research (ISD), Klinikum der Universität München (KUM), Ludwig-Maximilians-University (LMU), 81377 Munich, Germany.
Bernhagen J; Division of Vascular Biology, Institute for Stroke and Dementia Research (ISD), Klinikum der Universität München (KUM), Ludwig-Maximilians-University (LMU), 81377 Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany; Munich Heart Alliance, 80802 Munich, Germany. Electronic address: .
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Źródło:
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Structure (London, England : 1993) [Structure] 2022 Jun 02; Vol. 30 (6), pp. 787-790.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't; Comment
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Język:
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English
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Imprint Name(s):
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Publication: 2000- : Cambridge, Mass. : Cell Press
Original Publication: London : Current Biology, c1993-
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MeSH Terms:
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Macrophage Migration-Inhibitory Factors*/chemistry
Macrophage Migration-Inhibitory Factors*/metabolism
Allosteric Site ; Oxidation-Reduction
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Substance Nomenclature:
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0 (Macrophage Migration-Inhibitory Factors)
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Entry Date(s):
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Date Created: 20220606 Date Completed: 20220608 Latest Revision: 20220720
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Update Code:
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20240105
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DOI:
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10.1016/j.str.2022.05.005
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PMID:
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35660241
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In this issue of Structure, Skeens et al. provide insights into the structure and dynamics of an oxidized form of the atypical cytokine macrophage migration-inhibitory factor (MIF). The study unveils a surprising conformational susceptibility of MIF to ambient redox alterations and identifies redox-sensitive residues and latent allostery sites with functional relevance.
Competing Interests: Declaration of interests J.B. is an inventor on patent applications related to anti-MIF/anti-chemokine strategies in inflammatory and cardiovascular diseases. J.B. and M.B. are members of the m4 project team preclinical development of peptide-based chemokine receptor mimics as ligand-selective compounds for atherosclerotic diseases, a pre-seed competition award by the Bavarian State Ministry of Economic Affairs, State Development, and Energy.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Comment on: Structure. 2022 Jun 2;30(6):840-850.e6. (PMID: 35381187)
