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Tytuł:
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Homonuclear J-coupling spectroscopy using J-synchronized echo detection.
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Autorzy:
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DeVience SJ; Scalar Magnetics, LLC, 3 Harolwood Ct., Apt C, Windsor Mill, MD 21244, USA. Electronic address: .
Rosen MS; Athinoula A. Martinos Center for Biomedical Engineering, Massachusetts General Hospital, 149(th) Thirteenth St., Charlestown, MA 02129, USA; Department of Physics, Harvard University, 17 Oxford St., Cambridge, MA 02138, USA. Electronic address: .
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Źródło:
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Journal of magnetic resonance (San Diego, Calif. : 1997) [J Magn Reson] 2022 Aug; Vol. 341, pp. 107244. Date of Electronic Publication: 2022 May 23.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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Język:
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English
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Imprint Name(s):
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Publication: 2004- : San Diego : Elsevier
Original Publication: San Diego : Academic Press, c1997-2004.
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MeSH Terms:
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Magnetic Resonance Spectroscopy*/methods
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Contributed Indexing:
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Keywords: CPMG; J-Coupling; Spin echo train; Spin-lock induced crossing
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Entry Date(s):
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Date Created: 20220606 Date Completed: 20220802 Latest Revision: 20220914
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Update Code:
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20240105
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DOI:
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10.1016/j.jmr.2022.107244
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PMID:
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35667308
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In the strong coupling regime with J-coupling much larger than chemical shift differences, J-coupling spectroscopy enables spectral identification of molecules even when conventional NMR fails. While this classically required the presence of a heteronucleus, we recently showed that J-coupling spectra can be acquired in many homonuclear systems using spin-lock induced crossing (SLIC). Here, we present an alternative method using a spin echo train in lieu of a spin-locking SLIC pulse, which has a number of advantages. In particular, spin echo acquisition within the pulse train enables simultaneous collection of time and frequency data. The resulting 2D spectrum can be used to study dynamic spin evolution, and the time domain data can be averaged to create a 1D J-coupling spectrum with increased signal-to-noise ratio.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
