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Tytuł:
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Sevoflurane Sparing Effect of Morphine in Tegus (Salvator merianae) - A Preliminary Study.
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Autorzy:
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Carregaro AB; Department of Veterinary Medicine, School of Animal Science and Food Engineering, University of São Paulo, Pirassununga, SP, Brazil. Electronic address: .
Bressan TF; Department of Veterinary Medicine, School of Animal Science and Food Engineering, University of São Paulo, Pirassununga, SP, Brazil.
Xavier NV; Department of Veterinary Medicine, School of Animal Science and Food Engineering, University of São Paulo, Pirassununga, SP, Brazil.
Silva ANE; Department of Veterinary Medicine, School of Animal Science and Food Engineering, University of São Paulo, Pirassununga, SP, Brazil.
Justo AA; Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, SP, Brazil.
Myiashiro VY; Department of Veterinary Medicine, School of Animal Science and Food Engineering, University of São Paulo, Pirassununga, SP, Brazil.
Sanches MC; Department of Veterinary Medicine, School of Animal Science and Food Engineering, University of São Paulo, Pirassununga, SP, Brazil.
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Źródło:
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Topics in companion animal medicine [Top Companion Anim Med] 2022 Sep-Oct; Vol. 50, pp. 100678. Date of Electronic Publication: 2022 Jun 05.
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Typ publikacji:
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Clinical Trial, Veterinary; Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: New York, N.Y. : Elsevier
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MeSH Terms:
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Anesthetics, Inhalation*/pharmacology
Methyl Ethers*/pharmacology
Animals ; Cross-Over Studies ; Lizards ; Morphine/pharmacology ; Prospective Studies ; Sevoflurane
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Contributed Indexing:
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Keywords: lizard; opioid; reptile; sevoflurane
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Substance Nomenclature:
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0 (Anesthetics, Inhalation)
0 (Methyl Ethers)
38LVP0K73A (Sevoflurane)
76I7G6D29C (Morphine)
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Entry Date(s):
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Date Created: 20220608 Date Completed: 20220926 Latest Revision: 20220928
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Update Code:
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20240105
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DOI:
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10.1016/j.tcam.2022.100678
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PMID:
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35675902
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This study aimed to determine the minimum anesthetic concentration (MAC) of sevoflurane in tegus (Salvator merianae) and the morphine-sparing effect on this variable. In a prospective, non-blinded, crossover study, MAC was first determined in 6 tegus under sevoflurane anesthesia alone (MAC SEVO ) and then following intramuscular administration of morphine (10 mg/kg), administered 3 hour before sevoflurane anesthesia (MAC SEVO+MOR ). A standard bracketing technique was applied to determine the MAC by an electrical supramaximal noxious stimulus (50 Hz, 30 mA) delivered at the base of the tail of the tegus. The end-tidal sevoflurane fraction was reduced or increased by 10% in any evidence of negative or positive motor responses, respectively. The MAC was calculated as the mean of the 2 highest successive sevoflurane concentrations that permitted positive responses and the 2 lowest that prevented positive responses. Heart rate, esophageal temperature, and noninvasive mean arterial blood pressure were assessed every 10 minutes. The MAC was significantly different between MAC SEVO (2.41 ± 0.06%) and MAC SEVO+MORF (1.88 ± 0.43%) (P = .007), with a mean ± SD morphine-induced reduction in the sevoflurane MAC of 22 ± 18% (P = .0158). Heart rate, mean arterial blood pressure, and esophageal temperature did not differ between groups or within groups over time. Results showed that intramuscular premedication with 10 mg/kg morphine produced a sevoflurane sparing effect in tegus with no significant impact on cardiovascular variables.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
