Patient-reported systemic symptoms in women with silicone breast implants: a descriptive cohort study.

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Tytuł:: Patient-reported systemic symptoms in women with silicone breast implants: a descriptive cohort study.
Autorzy:: Spit KA; Internal Medicine, Amsterdam UMC, Locatie VUmc, Amsterdam, Noord-Holland, The Netherlands.
Scharff M; Internal Medicine, Amsterdam UMC, Locatie VUmc, Amsterdam, Noord-Holland, The Netherlands.
de Blok CJ; Department of Endocrinology, Amsterdam UMC, VUMC Location, Amsterdam, Noord-Holland, The Netherlands.
Niessen FB; Department of Plastic Surgery, Amsterdam UMC Locatie VUmc, Amsterdam, Noord-Holland, The Netherlands.
Bachour Y; Internal Medicine, Amsterdam UMC, Locatie VUmc, Amsterdam, Noord-Holland, The Netherlands.; Public Health Service of Amsterdam, Amsterdam, Noord-Holland, The Netherlands.
Nanayakkara PW; Internal Medicine, Amsterdam UMC, Locatie VUmc, Amsterdam, Noord-Holland, The Netherlands .
Źródło:: BMJ open [BMJ Open] 2022 Jun 09; Vol. 12 (6), pp. e057159. Date of Electronic Publication: 2022 Jun 09.
Typ publikacji:: Journal Article; Observational Study; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: [London] : BMJ Publishing Group Ltd, 2011-
MeSH Terms:: Breast Implantation*/adverse effects
Breast Implants*/adverse effects
Cohort Studies ; Female ; Humans ; Patient Reported Outcome Measures ; Silicones
References:: Immunol Res. 2017 Feb;65(1):25-36. (PMID: 27412295)
Semin Arthritis Rheum. 1994 Aug;24(1 Suppl 1):22-8. (PMID: 7801136)
J Plast Reconstr Aesthet Surg. 2019 Oct;72(10):1607-1615. (PMID: 31444054)
Arthritis Rheum. 2012 Jul;64(7):2319-27. (PMID: 22237992)
Mod Pathol. 2019 Feb;32(2):166-188. (PMID: 30206414)
BMJ. 2014 May 21;348:g3253. (PMID: 24850821)
Plast Reconstr Surg. 2001 Jan;107(1):206-13. (PMID: 11176625)
Immunol Res. 2017 Feb;65(1):120-128. (PMID: 27406737)
Clin Rheumatol. 2001;20(5):345-52. (PMID: 11642516)
Ann Intern Med. 2016 Feb 2;164(3):164-75. (PMID: 26550776)
Semin Arthritis Rheum. 1994 Aug;24(1 Suppl 1):44-53. (PMID: 7801139)
N Engl J Med. 2000 Mar 16;342(11):781-90. (PMID: 10717013)
J Rheumatol. 2003 Oct;30(10):2263-7. (PMID: 14528527)
Plast Reconstr Surg. 2012 Feb;129(2):327e-337e. (PMID: 22286447)
Clin Exp Rheumatol. 2014 Mar-Apr;32(2):256-8. (PMID: 24739521)
Lupus. 2017 Sep;26(10):1060-1063. (PMID: 28134037)
Immunol Res. 2013 Jul;56(2-3):293-8. (PMID: 23576058)
Breast Cancer Res Treat. 2016 Feb;156(1):65-72. (PMID: 26956974)
JAMA. 1996 Feb 28;275(8):616-21. (PMID: 8594243)
Semin Immunopathol. 2011 May;33(3):287-94. (PMID: 21369953)
Rheumatol Int. 2017 Aug;37(8):1405-1411. (PMID: 28466365)
Clin Exp Rheumatol. 2002 Mar-Apr;20(2):151-60. (PMID: 12051393)
Neth J Med. 2013 Dec;71(10):534-40. (PMID: 24394743)
Clin Rheumatol. 1995 Nov;14(6):667-72. (PMID: 8608686)
Eur J Clin Invest. 2011 Feb;41(2):203-11. (PMID: 20880074)
Semin Arthritis Rheum. 1994 Aug;24(1 Suppl 1):29-37. (PMID: 7801137)
Expert Rev Clin Immunol. 2022 Jan;18(1):15-29. (PMID: 34882509)
Arthritis Rheumatol. 2020 Jun;72(6):1026-1035. (PMID: 32266792)
Int J Epidemiol. 2018 Dec 1;47(6):1846-1854. (PMID: 30329056)
Aesthetic Plast Surg. 2020 Oct;44(5):1423-1437. (PMID: 32152711)
Rheumatology (Oxford). 2002 Feb;41(2):129-35; discussion 123-4. (PMID: 11886959)
JAMA Surg. 2017 Dec 01;152(12):1161-1168. (PMID: 29049466)
Ann Plast Surg. 2020 Jul;85(S1 Suppl 1):S82-S86. (PMID: 32530850)
Ann Surg. 2019 Jan;269(1):30-36. (PMID: 30222598)
Contributed Indexing:: Keywords: breast surgery; plastic & reconstructive surgery; rheumatology
Substance Nomenclature:: 0 (Silicones)
Entry Date(s):: Date Created: 20220609 Date Completed: 20220613 Latest Revision: 20220716
Update Code:: 20240105
PubMed Central ID:: PMC9185500
DOI:: 10.1136/bmjopen-2021-057159
PMID:: 35680258
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Objective: An unknown portion of women with silicone breast implants (SBI) report development of systemic symptoms, recently named as 'breast implant illness (BII)'. We aim to describe the symptoms and characteristics of women with SBI reporting these systemic symptoms and compare the clinical course of women who chose to keep their implants, to women who had their implants removed.
Design: Observational cohort study.
Setting: Specialised BII out-patient clinic at Amsterdam UMC, the Netherlands, from 2011 to 2020.
Participants: All women presenting to the BII clinic with SBI and systemic symptoms.
Results: 467 women were included for baseline analyses and 398 women for follow-up. Most frequently reported systemic symptoms at baseline included fatigue (88%), arthralgia (71%), morning stiffness (59%), myalgia (48%), cognitive impairment (33%), peripheral neurological symptoms (30%) and lymphadenopathy (22%). Furthermore, 56% reported pre-existing allergies at baseline and positive antinuclear antibodies were observed in 23%. At follow-up with a median of 3.3 years (IQR 2-4), 152 women had their implants removed on clinical grounds. Symptoms improved significantly in 65 women (43%), improved moderately in 37 women (24%), did not change in 37 women (24%) and deteriorated in 13 women (9%). Women who underwent explantation showed more improvement of their systemic symptoms compared with women who did not (OR 2.9, 95% CI 1.3 to 6.2). Additionally, women who underwent explantation within 10 years after implantation improved significantly better than women who got the implants removed after 10 years (p=0.007). Lastly, local symptoms decreased from 75% to 34% after implant removal (p<0.0001).
Conclusion: Most women with SBI who developed systemic symptoms experienced improvement after explantation, especially when removed within 10 years after implantation. Early recognition of the pattern of systemic symptoms in women with SBI is important and implant removal should be considered.
Competing Interests: Competing interests: None declared.
(© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

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