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Tytuł pozycji:

A Potential Role of Keratinocyte-Derived Bilirubin in Human Skin Yellowness and Its Amelioration by Sucrose Laurate/Dilaurate.

Tytuł:
A Potential Role of Keratinocyte-Derived Bilirubin in Human Skin Yellowness and Its Amelioration by Sucrose Laurate/Dilaurate.
Autorzy:
Fang B; The Procter & Gamble Company, Mason Business Center, Mason, OH 45040, USA.
Card PD; Department of Biosciences, Durham University, Stockton Road, Durham DH1 3LE, UK.
Chen J; The Procter & Gamble Company, Mason Business Center, Mason, OH 45040, USA.
Li L; The Procter & Gamble Company, Mason Business Center, Mason, OH 45040, USA.
Laughlin T; The Procter & Gamble Company, Mason Business Center, Mason, OH 45040, USA.
Jarrold B; The Procter & Gamble Company, Mason Business Center, Mason, OH 45040, USA.
Zhao W; The Procter & Gamble Company, Mason Business Center, Mason, OH 45040, USA.
Benham AM; Department of Biosciences, Durham University, Stockton Road, Durham DH1 3LE, UK.
Määttä AT; Department of Biosciences, Durham University, Stockton Road, Durham DH1 3LE, UK.
Hawkins TJ; Department of Biosciences, Durham University, Stockton Road, Durham DH1 3LE, UK.
Hakozaki T; The Procter & Gamble Company, Mason Business Center, Mason, OH 45040, USA.
Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 May 24; Vol. 23 (11). Date of Electronic Publication: 2022 May 24.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: Basel, Switzerland : MDPI, [2000-
MeSH Terms:
Bilirubin*/metabolism
Bilirubin*/pharmacology
Keratinocytes*/metabolism
Epidermis/metabolism ; Humans ; Skin/metabolism ; Sucrose/analogs & derivatives
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Grant Information:
not available The Procter & Gamble Company
Contributed Indexing:
Keywords: bilirubin; keratinocyte; oxidative stress; skin color; skin tone; skin yellowness; sucrose dilaurate; sucrose laurate
Substance Nomenclature:
05Q7CD0E49 (sucrose monolaurate)
57-50-1 (Sucrose)
RFM9X3LJ49 (Bilirubin)
Entry Date(s):
Date Created: 20220610 Date Completed: 20220613 Latest Revision: 20220716
Update Code:
20240105
PubMed Central ID:
PMC9180758
DOI:
10.3390/ijms23115884
PMID:
35682565
Czasopismo naukowe
Sallow and/or dull skin appearance is greatly attributable to the yellow components of skin tone. Bilirubin is a yellow chromophore known to be made in the liver and/or spleen and is transported throughout the body via the blood stream. Recent publications suggest bilirubin may be synthesized in other cells/organs, including the skin. We found human keratinocytes express the transcripts involved in bilirubin biosynthesis. In parallel, we also found human keratinocytes could indeed synthesize bilirubin in monolayer keratinocytes and in a 3D human skin-equivalent model. The synthesized amount was substantial enough to contribute to skin yellowness. In addition, oxidative stress enhanced bilirubin production. Using UnaG, a protein that forms a fluorescent species upon binding to bilirubin, we also visualized the intracellular expression of bilirubin in keratinocytes. Finally, we screened a compound library and discovered that the sucrose laurate/dilaurate (SDL) combination significantly reduced bilirubin levels, as well as bilirubin-mediated yellowness. In conclusion, bilirubin is indeed synthesized in epidermal keratinocytes and can be upregulated by oxidative stress, which could contribute to chronic or transient yellow skin tone appearance. Application of SDL diminishes bilirubin generation and may be a potential solution to mitigate yellowish and/or dull skin appearance.
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