Deep Brain Stimulation of the Medial Septal Area Can Modulate Gene Expression in the Hippocampus of Rats under Urethane Anesthesia.

Tytuł:: Deep Brain Stimulation of the Medial Septal Area Can Modulate Gene Expression in the Hippocampus of Rats under Urethane Anesthesia.
Autorzy:: Spivak YS; Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow 117485, Russia.
Karan AA; Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow 117485, Russia.
Dobryakova YV; Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow 117485, Russia.
Medvedeva TM; Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow 117485, Russia.
Markevich VA; Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow 117485, Russia.
Bolshakov AP; Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow 117485, Russia.
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 May 27; Vol. 23 (11). Date of Electronic Publication: 2022 May 27.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Basel, Switzerland : MDPI, [2000-
MeSH Terms:: Anesthesia*
Deep Brain Stimulation*
Septal Nuclei*
Animals ; Brain-Derived Neurotrophic Factor/metabolism ; Gene Expression ; Hippocampus ; Proto-Oncogene Proteins c-fos/genetics ; Proto-Oncogene Proteins c-fos/metabolism ; Rats ; Septum of Brain/metabolism ; Urethane
References:: Neuroscience. 1999 Jan;88(2):599-608. (PMID: 10197778)
Hippocampus. 2004;14(2):170-9. (PMID: 15098723)
Neuron. 2016 Jan 20;89(2):351-68. (PMID: 26777276)
Brain Res. 1982 Dec 9;252(2):227-37. (PMID: 6817846)
Mol Cell Neurosci. 2002 Dec;21(4):616-25. (PMID: 12504594)
Neurosci Lett. 1993 Feb 5;150(1):122-6. (PMID: 8469394)
J Biol Chem. 2000 Sep 15;275(37):28929-36. (PMID: 10852911)
Brain Res. 1986 Jul 30;379(1):63-7. (PMID: 3017509)
Hippocampus. 2020 Mar;30(3):175-191. (PMID: 31301167)
Front Synaptic Neurosci. 2013 Jul 30;5:2. (PMID: 23908628)
Behav Neural Biol. 1989 Nov;52(3):357-69. (PMID: 2556105)
Neuroreport. 1995 Nov 13;6(16):2166-70. (PMID: 8595195)
Science. 2015 Mar 6;347(6226):1138-42. (PMID: 25700174)
Exp Brain Res. 1984;56(2):243-56. (PMID: 6090194)
Biomed Res Int. 2014;2014:568587. (PMID: 25101288)
Brain Res. 1988 Jan 12;438(1-2):182-92. (PMID: 3345425)
Science. 2011 Apr 29;332(6029):595-9. (PMID: 21527714)
Brain Res. 1993 May 28;612(1-2):61-9. (PMID: 8330214)
Neuron. 2010 Jan 14;65(1):7-19. (PMID: 20152109)
Cell. 2018 Aug 9;174(4):1015-1030.e16. (PMID: 30096299)
Neurosci Res. 2015 Sep;98:1-8. (PMID: 25912092)
Front Neurosci. 2019 Sep 25;13:1020. (PMID: 31607855)
Cell. 2018 Aug 9;174(4):999-1014.e22. (PMID: 30096314)
Nucleic Acids Res. 1999 May 15;27(10):2211-8. (PMID: 10219095)
Front Neurosci. 2020 May 12;14:463. (PMID: 32477058)
Can J Physiol Pharmacol. 1987 May;65(5):1105-10. (PMID: 3621036)
J Cereb Blood Flow Metab. 2002 Jun;22(6):680-8. (PMID: 12045666)
Front Behav Neurosci. 2017 Mar 06;11:35. (PMID: 28321184)
Front Behav Neurosci. 2015 Jun 30;9:166. (PMID: 26175674)
Biochem Soc Symp. 2001;(67):131-40. (PMID: 11447829)
Neuron. 2020 Aug 19;107(4):731-744.e3. (PMID: 32526196)
Science. 1978 Jul 14;201(4351):160-3. (PMID: 663646)
Front Cell Neurosci. 2020 Oct 15;14:577912. (PMID: 33192323)
Neuroscience. 1982;7(9):2165-83. (PMID: 6292779)
Neuron. 2001 Dec 6;32(5):855-65. (PMID: 11738031)
Front Mol Neurosci. 2016 Jan 05;8:78. (PMID: 26778955)
Physiol Rev. 1995 Apr;75(2):393-427. (PMID: 7724668)
Exp Brain Res. 1992;88(1):78-90. (PMID: 1541364)
Behav Neurosci. 1990 Dec;104(6):849-55. (PMID: 2178347)
Front Neurosci. 2020 Dec 01;14:603373. (PMID: 33335473)
Molecules. 2022 Apr 27;27(9):. (PMID: 35566132)
Cereb Cortex. 2010 Dec;20(12):2939-47. (PMID: 20348156)
Neuroscience. 2009 Nov 10;163(4):1340-52. (PMID: 19665048)
J Neurosci. 1999 Aug 1;19(15):6661-72. (PMID: 10414995)
Nature. 2013 Jan 17;493(7432):327-37. (PMID: 23325215)
Nature. 1998 May 28;393(6683):373-7. (PMID: 9620801)
J Neurol Sci. 1995 Jul;131(1):8-14. (PMID: 7561953)
Nature. 2018 Nov;563(7729):72-78. (PMID: 30382198)
J Cereb Blood Flow Metab. 2020 May;40(5):1117-1131. (PMID: 31242047)
Neuron. 2020 Apr 22;106(2):218-235. (PMID: 32325058)
Neuroscience. 1983;8(2):291-7. (PMID: 6302560)
Physiol Rev. 2001 Jul;81(3):1065-96. (PMID: 11427692)
Grant Information:: 22-25-00479 Russian Science Foundation
Contributed Indexing:: Keywords: bdnf; deep brain stimulation; dorsal hippocampus; early genes; inflammation; ngf; septum; ventral hippocampus
Substance Nomenclature:: 0 (Brain-Derived Neurotrophic Factor)
0 (Proto-Oncogene Proteins c-fos)
3IN71E75Z5 (Urethane)
Entry Date(s):: Date Created: 20220610 Date Completed: 20220613 Latest Revision: 20220716
Update Code:: 20240105
PubMed Central ID:: PMC9181580
DOI:: 10.3390/ijms23116034
PMID:: 35682713
: Czasopismo naukowe

Pełny tekst

We studied the effects of stimulation of the medial septal area on the gene expression in the dorsal and ventral hippocampus. Rats under urethane anesthesia were implanted with a recording electrode in the right hippocampus and stimulating electrode in the dorsal medial septum (dMS) or medial septal nucleus (MSN). After one-hour-long deep brain stimulation, we collected ipsi- and contralateral dorsal and ventral hippocampi. Quantitative PCR showed that deep brain stimulation did not cause any changes in the intact contralateral dorsal and ventral hippocampi. A comparison of ipsi- and contralateral hippocampi in the control unstimulated animals showed that electrode implantation in the ipsilateral dorsal hippocampus led to a dramatic increase in the expression of immediate early genes ( c-fos, arc, egr1, npas4 ), neurotrophins ( ngf, bdnf ) and inflammatory cytokines ( il1b and tnf , but not il6 ) not only in the area close to implantation site but also in the ventral hippocampus. Moreover, the stimulation of MSN but not dMS further increased the expression of c-fos, egr1, npas4, bdnf, and tnf in the ipsilateral ventral but not dorsal hippocampus. Our data suggest that the activation of medial septal nucleus can change the gene expression in ventral hippocampal cells after their priming by other stimuli.

Zaloguj się, aby uzyskać dostęp do pełnego tekstu.

Informacja