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Tytuł:
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Biogenesis and engineering of interleukin 12 family cytokines.
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Autorzy:
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Hildenbrand K; Department of Chemistry, Technical University of Munich, 85748 Garching, Germany.
Aschenbrenner I; Department of Chemistry, Technical University of Munich, 85748 Garching, Germany.
Franke FC; Department of Chemistry, Technical University of Munich, 85748 Garching, Germany.
Devergne O; Sorbonne Université, INSERM, CNRS, Centre d'Immunologie et des Maladies Infectieuses (Cimi-Paris), 75 013 Paris, France. Electronic address: .
Feige MJ; Department of Chemistry, Technical University of Munich, 85748 Garching, Germany. Electronic address: .
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Źródło:
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Trends in biochemical sciences [Trends Biochem Sci] 2022 Nov; Vol. 47 (11), pp. 936-949. Date of Electronic Publication: 2022 Jun 10.
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Typ publikacji:
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Journal Article; Review; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: Cambridge (Eng) : Elsevier Trends Journals
Original Publication: Amsterdam, Published for the International Union of Biochemistry by Elsevier Scientific Pub. Co.
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MeSH Terms:
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Cytokines*
Interleukin-12*/chemistry
Interleukin-12*/metabolism
Interleukin-23/chemistry ; Interleukin-23/metabolism ; Molecular Chaperones/metabolism
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Contributed Indexing:
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Keywords: chaperones; endoplasmic reticulum quality control; heterodimeric cytokines; interleukin structure; protein engineering; subunit sharing
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Substance Nomenclature:
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0 (Cytokines)
0 (Interleukin-23)
0 (Molecular Chaperones)
187348-17-0 (Interleukin-12)
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Entry Date(s):
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Date Created: 20220612 Date Completed: 20221018 Latest Revision: 20221201
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Update Code:
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20240105
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DOI:
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10.1016/j.tibs.2022.05.005
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PMID:
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35691784
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Interleukin 12 (IL-12) family cytokines are secreted proteins that regulate immune responses. Each family member is a heterodimer and nature uses shared building blocks to assemble the functionally distinct IL-12 cytokines. In recent years we have gained insights into the molecular principles and cellular regulation of IL-12 family biogenesis. For each of the family members, generally one subunit depends on its partner to acquire its native structure and be secreted from immune cells. If unpaired, molecular chaperones retain these subunits in cells. This allows cells to regulate and control secretion of the highly potent IL-12 family cytokines. Molecular insights gained into IL-12 family biogenesis, structure, and function now allow us to engineer IL-12 family cytokines to develop novel immunotherapeutic approaches.
Competing Interests: Declaration of interests No interests are declared.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
