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Tytuł pozycji:

Diethyl phthalate (DEP) perturbs nitrogen metabolism in Saccharomyces cerevisiae.

Tytuł:
Diethyl phthalate (DEP) perturbs nitrogen metabolism in Saccharomyces cerevisiae.
Autorzy:
Goh CJH; Bioinformatics Institute, 30 Biopolis Street, Singapore, 138671, Singapore.
Cui L; Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, 1 CREATE Way, Singapore, 138602, Singapore.
Wong JH; Bioinformatics Institute, 30 Biopolis Street, Singapore, 138671, Singapore.
Lewis J; Singapore Institute of Food and Biotechnology Innovation, 61 Biopolis Drive, Singapore, 138673, Singapore.
Goh M; Singapore Institute of Food and Biotechnology Innovation, 61 Biopolis Drive, Singapore, 138673, Singapore.
Kong KW; Institute of Molecular and Cellular Biology, 61 Biopolis Drive, Singapore, 138673, Singapore.
Yang LK; Singapore Institute of Food and Biotechnology Innovation, 61 Biopolis Drive, Singapore, 138673, Singapore.
Alfatah M; Bioinformatics Institute, 30 Biopolis Street, Singapore, 138671, Singapore.
Kanagasundaram Y; Singapore Institute of Food and Biotechnology Innovation, 61 Biopolis Drive, Singapore, 138673, Singapore.
Hoon S; Institute of Molecular and Cellular Biology, 61 Biopolis Drive, Singapore, 138673, Singapore.
Arumugam P; Singapore Institute of Food and Biotechnology Innovation, 61 Biopolis Drive, Singapore, 138673, Singapore. .; School of Biological Sciences, Nanyang Technological University, Singapore, 637551, Singapore. .
Źródło:
Scientific reports [Sci Rep] 2022 Jun 17; Vol. 12 (1), pp. 10237. Date of Electronic Publication: 2022 Jun 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Original Publication: London : Nature Publishing Group, copyright 2011-
MeSH Terms:
Phthalic Acids*/metabolism
Phthalic Acids*/toxicity
Saccharomyces cerevisiae Proteins*/genetics
Saccharomyces cerevisiae Proteins*/metabolism
Amino Acids/metabolism ; Humans ; Nitrogen/metabolism ; Nuclear Proteins/metabolism ; RNA-Binding Proteins/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism
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Substance Nomenclature:
0 (Amino Acids)
0 (Nuclear Proteins)
0 (Phthalic Acids)
0 (RNA-Binding Proteins)
0 (STP1 protein, S cerevisiae)
0 (Saccharomyces cerevisiae Proteins)
0 (Transcription Factors)
N762921K75 (Nitrogen)
UF064M00AF (diethyl phthalate)
Entry Date(s):
Date Created: 20220617 Date Completed: 20220621 Latest Revision: 20220819
Update Code:
20240105
PubMed Central ID:
PMC9205984
DOI:
10.1038/s41598-022-14284-w
PMID:
35715465
Czasopismo naukowe
Phthalates are ubiquitously used as plasticizers in various consumer care products. Diethyl phthalate (DEP), one of the main phthalates, elicits developmental and reproductive toxicities but the underlying mechanisms are not fully understood. Chemogenomic profiling of DEP in S. cerevisiae revealed that two transcription factors Stp1 and Dal81 involved in the Ssy1-Ptr5-Ssy5 (SPS) amino acid-sensing pathway provide resistance to DEP. Growth inhibition of yeast cells by DEP was stronger in poor nitrogen medium in comparison to nitrogen-rich medium. Addition of amino acids to nitrogen-poor medium suppressed DEP toxicity. Catabolism of amino acids via the Ehrlich pathway is required for suppressing DEP toxicity. Targeted metabolite analyses showed that DEP treatment alters the amino acid profile of yeast cells. We propose that DEP inhibits the growth of yeast cells by affecting nitrogen metabolism and discuss the implications of our findings on DEP-mediated toxic effects in humans.
(© 2022. The Author(s).)
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