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Tytuł:
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Skin cancer risk factors among Black South Africans-The Johannesburg Cancer Study, 1995-2016.
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Autorzy:
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Ndlovu BC; South African Field Epidemiology Training Program, National Institute for Communicable Diseases, Division of the National Health Laboratory Service, Johannesburg, South Africa.; National Cancer Registry, National Health Laboratory Service, Johannesburg, South Africa.; School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Sengayi-Muchengeti M; National Cancer Registry, National Health Laboratory Service, Johannesburg, South Africa.; School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; South African DSI-NRF Centre of Excellence in Epidemiological Modeling and Analysis (SACEMA), Stellenbosch University, Stellenbosch, South Africa.
Wright CY; Environment and Health Research Unit, South African Medical Research Council, Pretoria, South Africa.; Department of Geography, Geoinformatics and Meteorology, University of Pretoria, Pretoria, South Africa.
Chen WC; National Cancer Registry, National Health Laboratory Service, Johannesburg, South Africa.; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Kuonza L; South African Field Epidemiology Training Program, National Institute for Communicable Diseases, Division of the National Health Laboratory Service, Johannesburg, South Africa.; School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Singh E; National Cancer Registry, National Health Laboratory Service, Johannesburg, South Africa.; School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
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Źródło:
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Immunity, inflammation and disease [Immun Inflamm Dis] 2022 Jul; Vol. 10 (7), pp. e623.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: [Oxford] : John Wiley and Sons Ltd, [2013]-
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MeSH Terms:
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HIV Infections*/epidemiology
Skin Neoplasms*/epidemiology
Case-Control Studies ; Female ; Humans ; Male ; Melanoma ; Risk Factors ; South Africa/epidemiology ; Melanoma, Cutaneous Malignant
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References:
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Contributed Indexing:
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Keywords: Black population; South Africa; keratinocyte skin cancer; melanoma skin cancer; risk factors
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Entry Date(s):
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Date Created: 20220627 Date Completed: 20220629 Latest Revision: 20231213
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Update Code:
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20240105
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PubMed Central ID:
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PMC9168546
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DOI:
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10.1002/iid3.623
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PMID:
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35759242
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Background: The Black population has lower skin cancer incidence compared to White, Indian/Asian, and Mixed-race populations in South Africa; however, skin cancer still exists in the Black population. The aim of this study is to identify risk factors associated with skin cancer among Black South Africans.
Materials and Methods: A case-control study was conducted. Cases were patients with keratinocyte cancers (KCs) and/or melanoma skin cancers (MSCs) and controls were cardiovascular patients. Sociodemographic exposures, environmental health variables, smoking, and HIV status were assessed. Stepwise logistic regression was used to identify risk factors associated with KCs and MSCs.
Results: The KCs histological subtypes showed that there were more squamous cell carcinomas (SCCs) (78/160 in females, and 72/160 in males) than basal cell carcinomas (BCCs). The SCC lesions were mostly found on the skin of the head and neck in males (51%, 38/72) and on the trunk in females (46%, 36/78). MSC was shown to affect the skin of the lower limbs in both males (68%, 27/40) and females (59%, 36/61). Using females as a reference group, when age, current place of residency, type of cooking fuel used, smoking, and HIV status were adjusted for, males had an odds ratio (OR) of 2.04 for developing KCs (confidence interval [CI]: 1.08-3.84, p = .028). Similarly, when age, current place of residency, and place of cooking (indoors or outdoors) were adjusted for, males had an OR of 2.26 for developing MSC (CI: 1.19-4.29, p = .012).
Conclusions: Differences in the anatomical distribution of KCs by sex suggest different risk factors between sexes. There is a positive association between being male, smoking, rural dwelling, and a positive HIV status with KCs and being male and rural dwelling with MSC. The rural dwelling was a newly found association with skin cancer and warrants further investigation.
(© 2022 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.)
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