Comprehensive analysis of CXCR family members in lung adenocarcinoma with prognostic values.

Szczegóły
Abstrakt

Tytuł:: Comprehensive analysis of CXCR family members in lung adenocarcinoma with prognostic values.
Autorzy:: Hu LT; Basic Medical College, Jiamusi University, Jiamusi, 154002, Heilongjiang, China.; Key Laboratory of Microecology-Immune Regulatory Network and Related Diseases, Jiamusi, 154002, Heilongjiang, China.
Deng WJ; Basic Medical College, Jiamusi University, Jiamusi, 154002, Heilongjiang, China.; Key Laboratory of Microecology-Immune Regulatory Network and Related Diseases, Jiamusi, 154002, Heilongjiang, China.
Chu ZS; Basic Medical College, Jiamusi University, Jiamusi, 154002, Heilongjiang, China.; Key Laboratory of Microecology-Immune Regulatory Network and Related Diseases, Jiamusi, 154002, Heilongjiang, China.
Sun L; Key Laboratory of Microecology-Immune Regulatory Network and Related Diseases, Jiamusi, 154002, Heilongjiang, China.; First Affiliated Hospital, Jiamusi University, Jiamusi, 154002, Heilongjiang, China.
Zhang CB; Department of Medical Technology, Collaborative Innovation Center for Translation Medical Testing and Application Technology Zhangzhou, Zhang Zhou Health Vocational College, Zhangzhou, 363000, Fujian Province, China.
Lu SZ; Basic Medical College, Jiamusi University, Jiamusi, 154002, Heilongjiang, China.; Key Laboratory of Microecology-Immune Regulatory Network and Related Diseases, Jiamusi, 154002, Heilongjiang, China.
Weng JR; Key Laboratory of Microecology-Immune Regulatory Network and Related Diseases, Jiamusi, 154002, Heilongjiang, China.; Stomatological Hospital, Jiamusi University, Jiamusi, 154002, Heilongjiang, China.
Ren QS; Key Laboratory of Microecology-Immune Regulatory Network and Related Diseases, Jiamusi, 154002, Heilongjiang, China.; Stomatological Hospital, Jiamusi University, Jiamusi, 154002, Heilongjiang, China.
Dong XY; Basic Medical College, Jiamusi University, Jiamusi, 154002, Heilongjiang, China.; Key Laboratory of Microecology-Immune Regulatory Network and Related Diseases, Jiamusi, 154002, Heilongjiang, China.
Li WD; Basic Medical College, Jiamusi University, Jiamusi, 154002, Heilongjiang, China.; Key Laboratory of Microecology-Immune Regulatory Network and Related Diseases, Jiamusi, 154002, Heilongjiang, China.
Li XB; Key Laboratory of Microecology-Immune Regulatory Network and Related Diseases, Jiamusi, 154002, Heilongjiang, China.; First Affiliated Hospital, Jiamusi University, Jiamusi, 154002, Heilongjiang, China.
Du YT; Department of Laboratory, Cancer Hospital of China Medical University, Shenyang,, Liaoning Province, China.
Li Y; Basic Medical College, Jiamusi University, Jiamusi, 154002, Heilongjiang, China. .; Key Laboratory of Microecology-Immune Regulatory Network and Related Diseases, Jiamusi, 154002, Heilongjiang, China. .
Wang WQ; Basic Medical College, Jiamusi University, Jiamusi, 154002, Heilongjiang, China. .; Key Laboratory of Microecology-Immune Regulatory Network and Related Diseases, Jiamusi, 154002, Heilongjiang, China. .
Źródło:: BMC pulmonary medicine [BMC Pulm Med] 2022 Jun 29; Vol. 22 (1), pp. 259. Date of Electronic Publication: 2022 Jun 29.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: London : BioMed Central, [2001]-
MeSH Terms:: Adenocarcinoma*/pathology
Adenocarcinoma of Lung*/genetics
Adenocarcinoma of Lung*/pathology
Lung Neoplasms*/pathology
Humans ; Prognosis ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
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Grant Information:: grant no. 81272854 The present study was supported by the National Natural Science Foundation of China; grant no. 81272854 The present study was supported by the National Natural Science Foundation of China; grant no. 81272854 The present study was supported by the National Natural Science Foundation of China; grant no. 81272854 The present study was supported by the National Natural Science Foundation of China; grant no. 81272854 The present study was supported by the National Natural Science Foundation of China; grant no. 81272854 The present study was supported by the National Natural Science Foundation of China; grant no. 81272854 The present study was supported by the National Natural Science Foundation of China; grant no. 81272854 The present study was supported by the National Natural Science Foundation of China; grant no. 81272854 The present study was supported by the National Natural Science Foundation of China; grant no. 81272854 The present study was supported by the National Natural Science Foundation of China; grant no. 81272854 The present study was supported by the National Natural Science Foundation of China; grant no. 81272854 The present study was supported by the National Natural Science Foundation of China; grant no. 81272854 The present study was supported by the National Natural Science Foundation of China; grant no. 81272854 The present study was supported by the National Natural Science Foundation of China; grant no. ZD2019H008 Key Projects of Natural Science Foundation of Heilongjiang Province; grant no. ZD2019H008 Key Projects of Natural Science Foundation of Heilongjiang Province; grant no. ZD2019H008 Key Projects of Natural Science Foundation of Heilongjiang Province; grant no. ZD2019H008 Key Projects of Natural Science Foundation of Heilongjiang Province; grant no. ZD2019H008 Key Projects of Natural Science Foundation of Heilongjiang Province; grant no. ZD2019H008 Key Projects of Natural Science Foundation of Heilongjiang Province; grant no. ZD2019H008 Key Projects of Natural Science Foundation of Heilongjiang Province; grant no. ZD2019H008 Key Projects of Natural Science Foundation of Heilongjiang Province; grant no. ZD2019H008 Key Projects of Natural Science Foundation of Heilongjiang Province; grant no. ZD2019H008 Key Projects of Natural Science Foundation of Heilongjiang Province; grant no. ZD2019H008 Key Projects of Natural Science Foundation of Heilongjiang Province; grant no. ZD2019H008 Key Projects of Natural Science Foundation of Heilongjiang Province; grant no. ZD2019H008 Key Projects of Natural Science Foundation of Heilongjiang Province; grant no. ZD2019H008 Key Projects of Natural Science Foundation of Heilongjiang Province; grant no. 2019-KYYWF-1334 Excellent Innovation Team Construction Project of Basic Scientific Research Business Fee of Provincial Colleges and Universities in Heilongjiang Province; grant no. 2019-KYYWF-1334 Excellent Innovation Team Construction Project of Basic Scientific Research Business Fee of Provincial Colleges and Universities in Heilongjiang Province; grant no. 2019-KYYWF-1334 Excellent Innovation Team Construction Project of Basic Scientific Research Business Fee of Provincial Colleges and Universities in Heilongjiang Province; grant no. 2019-KYYWF-1334 Excellent Innovation Team Construction Project of Basic Scientific Research Business Fee of Provincial Colleges and Universities in Heilongjiang Province; grant no. 2019-KYYWF-1334 Excellent Innovation Team Construction Project of Basic Scientific Research Business Fee of Provincial Colleges and Universities in Heilongjiang Province; grant no. 2019-KYYWF-1334 Excellent Innovation Team Construction Project of Basic Scientific Research Business Fee of Provincial Colleges and Universities in Heilongjiang Province; grant no. 2019-KYYWF-1334 Excellent Innovation Team Construction Project of Basic Scientific Research Business Fee of Provincial Colleges and Universities in Heilongjiang Province; grant no. 2019-KYYWF-1334 Excellent Innovation Team Construction Project of Basic Scientific Research Business Fee of Provincial Colleges and Universities in Heilongjiang Province; grant no. 2019-KYYWF-1334 Excellent Innovation Team Construction Project of Basic Scientific Research Business Fee of Provincial Colleges and Universities in Heilongjiang Province; grant no. 2019-KYYWF-1334 Excellent Innovation Team Construction Project of Basic Scientific Research Business Fee of Provincial Colleges and Universities in Heilongjiang Province; grant no. 2019-KYYWF-1334 Excellent Innovation Team Construction Project of Basic Scientific Research Business Fee of Provincial Colleges and Universities in Heilongjiang Province; grant no. 2019-KYYWF-1334 Excellent Innovation Team Construction Project of Basic Scientific Research Business Fee of Provincial Colleges and Universities in Heilongjiang Province; grant no. 2019-KYYWF-1334 Excellent Innovation Team Construction Project of Basic Scientific Research Business Fee of Provincial Colleges and Universities in Heilongjiang Province; grant no. 2019-KYYWF-1334 Excellent Innovation Team Construction Project of Basic Scientific Research Business Fee of Provincial Colleges and Universities in Heilongjiang Province; grant no. UNPYSCT-2020054 Young innovative talents training project of regular undergraduate colleges and universities in Heilongjiang Province; grant no. UNPYSCT-2020054 Young innovative talents training project of regular undergraduate colleges and universities in Heilongjiang Province; grant no. UNPYSCT-2020054 Young innovative talents training project of regular undergraduate colleges and universities in Heilongjiang Province; grant no. UNPYSCT-2020054 Young innovative talents training project of regular undergraduate colleges and universities in Heilongjiang Province; grant no. UNPYSCT-2020054 Young innovative talents training project of regular undergraduate colleges and universities in Heilongjiang Province; grant no. UNPYSCT-2020054 Young innovative talents training project of regular undergraduate colleges and universities in Heilongjiang Province; grant no. UNPYSCT-2020054 Young innovative talents training project of regular undergraduate colleges and universities in Heilongjiang Province; grant no. UNPYSCT-2020054 Young innovative talents training project of regular undergraduate colleges and universities in Heilongjiang Province; grant no. UNPYSCT-2020054 Young innovative talents training project of regular undergraduate colleges and universities in Heilongjiang Province; grant no. UNPYSCT-2020054 Young innovative talents training project of regular undergraduate colleges and universities in Heilongjiang Province; grant no. UNPYSCT-2020054 Young innovative talents training project of regular undergraduate colleges and universities in Heilongjiang Province; grant no. UNPYSCT-2020054 Young innovative talents training project of regular undergraduate colleges and universities in Heilongjiang Province; grant no. UNPYSCT-2020054 Young innovative talents training project of regular undergraduate colleges and universities in Heilongjiang Province; grant no. UNPYSCT-2020054 Young innovative talents training project of regular undergraduate colleges and universities in Heilongjiang Province; JMSUBZ2019-01 Jiamusi University doctoral Special Research Fund launch project; JMSUBZ2019-01 Jiamusi University doctoral Special Research Fund launch project; JMSUBZ2019-01 Jiamusi University doctoral Special Research Fund launch project; JMSUBZ2019-01 Jiamusi University doctoral Special Research Fund launch project; JMSUBZ2019-01 Jiamusi University doctoral Special Research Fund launch project; JMSUBZ2019-01 Jiamusi University doctoral Special Research Fund launch project; JMSUBZ2019-01 Jiamusi University doctoral Special Research Fund launch project; JMSUBZ2019-01 Jiamusi University doctoral Special Research Fund launch project; JMSUBZ2019-01 Jiamusi University doctoral Special Research Fund launch project; JMSUBZ2019-01 Jiamusi University doctoral Special Research Fund launch project; JMSUBZ2019-01 Jiamusi University doctoral Special Research Fund launch project; JMSUBZ2019-01 Jiamusi University doctoral Special Research Fund launch project; JMSUBZ2019-01 Jiamusi University doctoral Special Research Fund launch project; JMSUBZ2019-01 Jiamusi University doctoral Special Research Fund launch project; No.19-112-4-092 Shenyang Science and Technology Plan Project; No.19-112-4-092 Shenyang Science and Technology Plan Project; No.19-112-4-092 Shenyang Science and Technology Plan Project; No.19-112-4-092 Shenyang Science and Technology Plan Project; No.19-112-4-092 Shenyang Science and Technology Plan Project; No.19-112-4-092 Shenyang Science and Technology Plan Project; No.19-112-4-092 Shenyang Science and Technology Plan Project; No.19-112-4-092 Shenyang Science and Technology Plan Project; No.19-112-4-092 Shenyang Science and Technology Plan Project; No.19-112-4-092 Shenyang Science and Technology Plan Project; No.19-112-4-092 Shenyang Science and Technology Plan Project; No.19-112-4-092 Shenyang Science and Technology Plan Project; No.19-112-4-092 Shenyang Science and Technology Plan Project; No.19-112-4-092 Shenyang Science and Technology Plan Project
Contributed Indexing:: Keywords: CXC chemokine receptors (CXCRs); Lung adenocarcinoma (LUAD); Prognostic values
Substance Nomenclature:: 0 (RNA, Messenger)
Entry Date(s):: Date Created: 20220629 Date Completed: 20220701 Latest Revision: 20220716
Update Code:: 20240105
PubMed Central ID:: PMC9245315
DOI:: 10.1186/s12890-022-02051-6
PMID:: 35768814
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Background: The expression profiles and molecular mechanisms of CXC chemokine receptors (CXCRs) in Lung adenocarcinoma (LUAD) have been extensively explored. However, the comprehensive prognostic values of CXCR members in LUAD have not yet been clearly identified.
Methods: Multiple available datasets, including Oncomine datasets, the cancer genome atlas (TCGA), HPA platform, GeneMANIA platform, DAVID platform and the tumor immune estimation resource (TIMER) were used to detect the expression of CXCRs in LUAD, as well as elucidate the significance and value of novel CXCRs-associated genes and signaling pathways in LUAD.
Results: The mRNA and/or protein expression of CXCR1, CXCR2, CXCR3, CXCR4, CXCR5 and CXCR6 displayed predominantly decreased in LUAD tissues as compared to normal tissues. On the contrary, compared with the normal tissues, the expression of CXCR7 was significantly increased in LUAD tissues. Subsequently, we constructed a network including CXCR family members and their 20 related genes, and the related GO functions assay showed that CXCRs connected with these genes participated in the process of LUAD through several signal pathways including Chemokine signaling pathway, Cytokine-cytokine receptor interaction and Neuroactive ligand-receptor interaction. TCGA and Timer platform revealed that the mRNA expression of CXCR family members was significantly related to individual cancer stages, cancer subtypes, patient's gender and the immune infiltration level. Finally, survival analysis showed that low mRNA expression levels of CXCR2 (HR = 0.661, and Log-rank P = 1.90e-02), CXCR3 (HR = 0.674, and Log-rank P = 1.00e-02), CXCR4 (HR = 0.65, and Log-rank P = 5.01e-03), CXCR5 (HR = 0.608, and Log-rank P = 4.80e-03) and CXCR6 (HR = 0.622, and Log-rank P = 1.85e-03) were significantly associated with shorter overall survival (OS), whereas high CXCR7 mRNA expression (HR = 1.604, and Log-rank P = 4.27e-03) was extremely related with shorter OS in patients.
Conclusion: Our findings from public databases provided a unique insight into expression characteristics and prognostic values of CXCR members in LUAD, which would be benefit for the understanding of pathogenesis, diagnosis, prognosis prediction and targeted treatment in LUAD.
(© 2022. The Author(s).)

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