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Tytuł pozycji:

Establishment of gender- and age-specific reference intervals for serum liver function tests among the elderly population in northeast China: a retrospective study.

Tytuł:
Establishment of gender- and age-specific reference intervals for serum liver function tests among the elderly population in northeast China: a retrospective study.
Autorzy:
Sun Z; Department of Laboratory Medicine, First Hospital of Jilin University, Changchun, China.
Chai J; Department of Laboratory Medicine, First Hospital of Jilin University, Changchun, China.
Zhou Q; Department of Pediatrics, First Hospital of Jilin University, Changchun, China.
Xu J; Department of Laboratory Medicine, First Hospital of Jilin University, Changchun, China.
Źródło:
Biochemia medica [Biochem Med (Zagreb)] 2022 Jun 15; Vol. 32 (2), pp. 020707.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Publication: 2012- : Zagreb : Croatian Society for Medical Biochemistry and Laboratory Medicine
Original Publication: Zagreb : Hrvatsko društvo medicinskih biokemičara
MeSH Terms:
Bilirubin*
gamma-Glutamyltransferase*
Adolescent ; Age Factors ; Aged ; Alanine Transaminase ; Aspartate Aminotransferases ; China ; Humans ; Liver Function Tests ; Reference Values ; Retrospective Studies
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Contributed Indexing:
Keywords: age; elderly population; gender; liver function; reference interval
Substance Nomenclature:
EC 2.3.2.2 (gamma-Glutamyltransferase)
EC 2.6.1.1 (Aspartate Aminotransferases)
EC 2.6.1.2 (Alanine Transaminase)
RFM9X3LJ49 (Bilirubin)
Entry Date(s):
Date Created: 20220708 Date Completed: 20220711 Latest Revision: 20220716
Update Code:
20240105
PubMed Central ID:
PMC9195600
DOI:
10.11613/BM.2022.020707
PMID:
35799982
Czasopismo naukowe
Introduction: Reference intervals (RIs) for younger population may not apply to the elderly population. The aim of this study was to establish gender- and age-specific RIs for serum liver function tests among the elderly population and to compare with younger population RIs currently used in China and other countries.
Materials and Methods: This was a retrospective study, and subjects (≥ 18 year-old) were recruited from the laboratory information system (LIS) at the First Hospital of Jilin University between April 2020 and April 2021. The following parameters were collected: aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), alkaline phosphatase (ALP), total protein (TP), albumin (ALB), total bilirubin (TBIL), and direct bilirubin (DBIL). The Tukey method was used to eliminate outliers. Reference intervals were established by the nonparametric method.
Results: A total of 23,597 healthy individuals were enrolled in the study. From all parameters AST, ALT, TP and ALB required no gender partition, while ALT, GGT, TP, ALB and DBIL required different partitions for age. Activities and concentrations of ALT, ALB, and TP showed a downward trend in the elderly aged 60-89. In contrast, DBIL showed a gradual upward trend.
Conclusion: The RIs for liver function tests among healthy elderly population were different from those among young population in China. There were apparent gender and age differences in the RIs of liver function for elderly and significant differences compared with national standards and RIs in other countries. Therefore, it is necessary to establish gender- and age-specific RIs for serum liver function tests among the elderly population.
Competing Interests: Potential conflict of interest None declared.
(Croatian Society of Medical Biochemistry and Laboratory Medicine.)

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