A systematic approach to reduce intraocular pressure for the treatment of glaucoma.

Szczegóły
Abstrakt

Tytuł:: A systematic approach to reduce intraocular pressure for the treatment of glaucoma.
Autorzy:: Huang YL; School of Medicine, National Cheng Kung University, Tainan, Taiwan.
Hsu YL; Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, Taiwan.
Yu YC; Department of Chemical Engineering, National Cheng Kung University, Tainan, Taiwan.
Huang HY; School of Medicine, National Cheng Kung University, Tainan, Taiwan.
Tsai RH; Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, Taiwan.
Cheng YT; School of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chou YL; Department of Electrical Engineering, National Cheng Kung University, Tainan, Taiwan.
Sun SY; School of Medicine, National Cheng Kung University, Tainan, Taiwan.
Wang LA; School of Medicine, National Cheng Kung University, Tainan, Taiwan.
Lin JY; Department of Chemical Engineering, National Cheng Kung University, Tainan, Taiwan.
Chen CC; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Hung JH; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Department of Ophthalmology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Ng IS; Department of Chemical Engineering, National Cheng Kung University, Tainan, Taiwan.
Źródło:: Biotechnology progress [Biotechnol Prog] 2022 Nov; Vol. 38 (6), pp. e3285. Date of Electronic Publication: 2022 Jul 14.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: <2010-> : Hoboken, NJ : Wiley-Blackwell
Original Publication: [New York, N.Y. : American Institute of Chemical Engineers, c1985-
MeSH Terms:: Intraocular Pressure*
Glaucoma*/drug therapy
Animals ; Swine ; Humans ; Nitric Oxide/therapeutic use ; Nitric Oxide Synthase/metabolism ; Nitric Oxide Synthase/therapeutic use
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Grant Information:: MOST 110-2221-E-006-030-MY3 Ministry of Science and Technology, Taiwan; MOST 110-2314-B-006-086-MY3 Ministry of Science and Technology, Taiwan
Contributed Indexing:: Keywords: contact lens; genetic E. coli; glaucoma; intraocular pressure (IOP); nitric oxide synthase
Substance Nomenclature:: 31C4KY9ESH (Nitric Oxide)
EC 1.14.13.39 (Nitric Oxide Synthase)
Entry Date(s):: Date Created: 20220708 Date Completed: 20221221 Latest Revision: 20221222
Update Code:: 20240105
DOI:: 10.1002/btpr.3285
PMID:: 35801317
: Czasopismo naukowe

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Glaucoma is the leading cause of irreversible blindness due to increased intraocular pressure (IOP) in the eye. We have developed a novel treatment option for glaucoma based on a real-time IOP-dependent nitric oxide synthase (NOS) and packed in a therapeutic contact lens to reduce the IOP. First, 1.6 nmole nitric oxide was produced from the genetic chassis, which was optimized for isopropyl β-d-1-thiogalactopyranoside (IPTG) induction in a T7 expression system. For biosafety concerns to human being, the csgAD genes responsible for curli biofilm formation in Escherichia coli were co-expressed with NOS in the designated NOSAD strain to strengthen the adherence of cells to the contact lens, thereby preventing the contamination into the eyes. Moreover, NOSAD is a diaminopimelic acid (DAP) auxotrophic strain, which cannot survive without supplementation of DAP and reached the critical consideration of biosafety to the environment. We also demonstrated that the nitric oxide diffusion was 3.6-times enhanced from penetration into the aqueous humor of porcine eyes. The deformation ratio of the contact lens was correlated to the change of IOP by using a digital image correlation (DIC) system in a porcine eye model. The novel systematic approach provides an alternative treatment for glaucoma patients in the future.
(© 2022 American Institute of Chemical Engineers.)

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