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Tytuł:
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Sleep as a window to target traumatic memories.
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Autorzy:
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van der Heijden AC; Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Psychiatry, Department Anatomy & Neuroscience, Boelelaan 1117, Amsterdam, the Netherlands; Amsterdam Neuroscience, Mood Anxiety Psychosis Stress Sleep, Amsterdam, the Netherlands. Electronic address: .
van den Heuvel OA; Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Psychiatry, Department Anatomy & Neuroscience, Boelelaan 1117, Amsterdam, the Netherlands; Amsterdam Neuroscience, Compulsivity Impulsivity and Attention, Amsterdam, the Netherlands.
van der Werf YD; Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Psychiatry, Department Anatomy & Neuroscience, Boelelaan 1117, Amsterdam, the Netherlands; Amsterdam Neuroscience, Compulsivity Impulsivity and Attention, Amsterdam, the Netherlands.
Talamini LM; University of Amsterdam, Dept. of Psychology, Brain & Cognition, Nieuwe Achtergracht 129B, 1018 WS Amsterdam, the Netherlands.
van Marle HJF; Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Psychiatry, Department Anatomy & Neuroscience, Boelelaan 1117, Amsterdam, the Netherlands; Amsterdam Neuroscience, Mood Anxiety Psychosis Stress Sleep, Amsterdam, the Netherlands; GGZ inGeest Mental Health Care, Amstelveenseweg 589, 1081 JC Amsterdam, the Netherlands.
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Źródło:
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Neuroscience and biobehavioral reviews [Neurosci Biobehav Rev] 2022 Sep; Vol. 140, pp. 104765. Date of Electronic Publication: 2022 Jul 05.
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Typ publikacji:
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Journal Article; Review; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: New York Ny : Pergamon Press
Original Publication: Fayetteville, N. Y., ANKHO International Inc.
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MeSH Terms:
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Memory Consolidation*
Stress Disorders, Post-Traumatic*
Humans ; Memory ; Sleep
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Contributed Indexing:
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Keywords: Memory consolidation; PTSD; Sleep; Targeted memory reactivation (TMR); Treatment
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Entry Date(s):
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Date Created: 20220708 Date Completed: 20220830 Latest Revision: 20220913
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Update Code:
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20240105
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DOI:
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10.1016/j.neubiorev.2022.104765
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PMID:
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35803396
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Post-traumatic stress disorder (PTSD) is a severe psychiatric disorder in which traumatic memories result in flashbacks and nightmares. With one-third of patients not responding to standard exposure-based psychotherapy, new treatment strategies are needed. Sleep offers a unique time window to enhance therapeutic efficacy. Traumatic memories that are neutralized in therapy need to be stored back into memory (consolidated) during sleep to solidify the treatment effect. New basic research shows that memory consolidation can be enhanced by presenting sounds or scents that were linked to the memory at encoding, again during sleep. This procedure, termed targeted memory reactivation (TMR), has, despite its clinical potential, not been tested in (PTSD) patients. In this narrative review, we explore the potential of TMR as a new sleep-based treatment for PTSD. First we provide the necessary background on the memory and sleep principles underlying PTSD as well as the present applications and conditional factors of TMR. Then, we will discuss the outstanding questions and most promising experimental avenues when testing TMR to treat traumatic memories.
(Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.)
