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Tytuł:
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Neonatal hemolytic disease due to anti-Diego antibody: a case report.
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Autorzy:
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Fu Y; Department of Respiratory Medicine, Baoji Maternity and Child Health Care Hospital, Children's Hospital of Baoji, Affiliated Hospital of Shaanxi University of Chinese Medicine, Baoji, 721000, Shaanxi, China. .
Liu Y; Department of Blood Transfusion, Baoji Maternity and Child Health Care Hospital, Children's Hospital of Baoji, Affiliated Hospital of Shaanxi University of Chinese Medicine, Baoji, 721000, Shaanxi, China.
Yang Z; Department of Blood Transfusion, Baoji Maternity and Child Health Care Hospital, Children's Hospital of Baoji, Affiliated Hospital of Shaanxi University of Chinese Medicine, Baoji, 721000, Shaanxi, China.
An Y; Department of Blood Transfusion, Baoji Maternity and Child Health Care Hospital, Children's Hospital of Baoji, Affiliated Hospital of Shaanxi University of Chinese Medicine, Baoji, 721000, Shaanxi, China.
Su J; Department of Neonatology, Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine, The Second People's Hospital of Zhuhai, Zhuhai, 519020, Guangdong, China.
Hu S; Department of Neonatology, Baoji Maternity and Child Health Care Hospital, Children's Hospital of Baoji, Affiliated Hospital of Shaanxi University of Chinese Medicine, Baoji, 721000, Shaanxi, China.
Luo L; Department of Neonatology, Baoji Maternity and Child Health Care Hospital, Children's Hospital of Baoji, Affiliated Hospital of Shaanxi University of Chinese Medicine, Baoji, 721000, Shaanxi, China.
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Źródło:
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Journal of medical case reports [J Med Case Rep] 2022 Jul 13; Vol. 16 (1), pp. 274. Date of Electronic Publication: 2022 Jul 13.
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Typ publikacji:
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Case Reports; Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: [London] : BioMed Central, [2007-
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MeSH Terms:
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Cesarean Section*/adverse effects
Erythroblastosis, Fetal*/etiology
Erythroblastosis, Fetal*/therapy
Antibodies ; Coombs Test ; Female ; Hemolysis ; Humans ; Infant, Newborn ; Male ; Phototherapy ; Pregnancy
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References:
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Contributed Indexing:
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Keywords: Anti-Diegoa antibody; Case report; Neonatal hemolytic disease
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Substance Nomenclature:
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0 (Antibodies)
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Entry Date(s):
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Date Created: 20220712 Date Completed: 20220714 Latest Revision: 20220716
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Update Code:
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20240105
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PubMed Central ID:
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PMC9277956
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DOI:
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10.1186/s13256-022-03516-2
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PMID:
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35820960
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Background: The Diego a antigen commonly occurs in certain Asian and South American Indian populations. In general, hemolysis caused by anti-Diego a antigen is not severe, and exchange transfusion is rarely needed. Here, we report a neonate with moderate hemolytic disease caused by anti-Diego a antigen in the Baoji area of China.
Case Presentation: A 39-week gestation male newborn of Han nationality was delivered by second cesarean section because of scarred uterus. The newborn's birth weight was 3700 g with an Apgar score of 9. Four hours after delivery, transcutaneous bilirubin test revealed a level of 17 mg/dl. After 23 hours, the neonate developed anemia and hyperbilirubinemia. Bacterium, virus and other pathogens, as well as tests for arcuate and glucose-6-phosphate dehydrogenase, were all negative. Direct antiglobulin test of the neonate was positive. Diego a antigens of the baby and his father were positive, while his mother was negative. The newborn was successfully cured with phototherapy and one-dose intravenous injection of human albumin.
Conclusions: It is important to consider and test for the anti-Diego a antibody in cases of hemolytic disease of the newborn of the Han ethnicities of China.
(© 2022. The Author(s).)
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