The vitamin D receptor gene variants, ApaI, TaqI, BsmI, and FokI in diabetic foot ulcer and their association with oxidative stress.

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Tytuł:: The vitamin D receptor gene variants, ApaI, TaqI, BsmI, and FokI in diabetic foot ulcer and their association with oxidative stress.
Autorzy:: Klashami ZN; Department of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.; Metabolic Disorders Research Centre, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Ahrabi NZ; Department of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran. .
Ahrabi YS; Department of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
Hasanzad M; Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.; Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Asadi M; Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Amoli MM; Metabolic Disorders Research Centre, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. .
Źródło:: Molecular biology reports [Mol Biol Rep] 2022 Sep; Vol. 49 (9), pp. 8627-8639. Date of Electronic Publication: 2022 Jul 20.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Dordrecht, Boston, Reidel.
MeSH Terms:: Diabetes Mellitus, Type 2*/complications
Diabetes Mellitus, Type 2*/genetics
Diabetic Foot*/genetics
Oxidative Stress*/genetics
Receptors, Calcitriol*/genetics
Vitamin D Deficiency*/genetics
Case-Control Studies ; Genetic Predisposition to Disease ; Genotype ; Humans ; Polymorphism, Single Nucleotide ; Thiobarbituric Acid Reactive Substances ; Vitamin D
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Grant Information:: 1392-01-86-1550 Tehran University of Medical Sciences and Health Services
Contributed Indexing:: Keywords: Diabetic foot ulcer; Oxidative stress; Type 2 diabetes; Vitamin D; Vitamin D receptor gene polymorphisms
Substance Nomenclature:: 0 (Receptors, Calcitriol)
0 (Thiobarbituric Acid Reactive Substances)
0 (VDR protein, human)
1406-16-2 (Vitamin D)
Entry Date(s):: Date Created: 20220720 Date Completed: 20220913 Latest Revision: 20220921
Update Code:: 20240105
DOI:: 10.1007/s11033-022-07698-2
PMID:: 35857173
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Introduction: To date, numerous disorders have been linked to vitamin D deficiency. Several lines of evidence indicate a relationship between vitamin D deficiency and the risk of developing type 2 diabetes. It has been postulated that vitamin D may influence insulin activity, which can predispose individuals to develop type 2 diabetes.
Materials and Methods: In this case-control study, 262 patients with definite type 2 diabetes were enrolled, considering whether they were being affected by diabetic foot ulcers or not. The plasma levels of vitamin D and homocysteine were measured using ELISA, and the PCR-RFLP technique was utilized to determine allele and genotype frequencies. The antioxidant capacity of plasma samples of diabetic patients was analyzed using the thiobarbituric acid reactive substance (TBARS) and ferric reducing ability of plasma (FRAP) assays.
Results: The obtained results demonstrated no significant difference in the frequency of TaqI and BsmI polymorphisms between the case and control groups. However, the frequency of genotypes and alleles of the ApaI polymorphism in the VDR gene significantly differed between the case and control groups. A significant correlation was found between ApaI polymorphism and oxidative stress, as patients with the GG genotype had lower levels of TBARS than those with other genotypes. Furthermore, in the case group, patients with the CC genotype of BsmI showed a significant decrease in TBARS levels.
Discussion: It seems that the plasma levels of vitamin D do not differ between patients with or without diabetic foot ulcers; however, the presence of some VDR gene polymorphisms is thought to be involved in the development of diabetic foot ulcers via increasing oxidative stress.
(© 2022. The Author(s), under exclusive licence to Springer Nature B.V.)

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