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Tytuł:
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Pivotal roles for membrane phospholipids in axonal degeneration.
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Autorzy:
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Almasieh M; Department of Ophthalmology and Visual Sciences, McGill University, Montreal, Canada.
Faris H; Department of Ophthalmology and Visual Sciences, McGill University, Montreal, Canada.
Levin LA; Department of Ophthalmology and Visual Sciences, McGill University, Montreal, Canada; Department of Neurology and Neurosurgery, McGill University, Montreal, Canada. Electronic address: .
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Źródło:
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The international journal of biochemistry & cell biology [Int J Biochem Cell Biol] 2022 Sep; Vol. 150, pp. 106264. Date of Electronic Publication: 2022 Jul 19.
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Typ publikacji:
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Journal Article; Review; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: Amsterdam : Elsevier
Original Publication: Exeter, England ; Tarrytown, NY, U.S.A. : Pergamon, c1995-
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MeSH Terms:
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Phosphatidylserines*
Phospholipids*
Axons ; Humans ; Neurons ; Wallerian Degeneration
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Grant Information:
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PJT-162396 Canada CIHR
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Contributed Indexing:
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Keywords: Axon; Axonal degeneration; Phosphatidylserine; Phospholipids
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Substance Nomenclature:
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0 (Phosphatidylserines)
0 (Phospholipids)
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Entry Date(s):
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Date Created: 20220722 Date Completed: 20220830 Latest Revision: 20221025
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Update Code:
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20240105
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DOI:
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10.1016/j.biocel.2022.106264
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PMID:
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35868612
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Membrane phospholipids are critical components of several signaling pathways. Maintained in a variety of asymmetric distributions, their trafficking across the membrane can be induced by intra-, extra-, and intercellular events. A familiar example is the externalization of phosphatidylserine from the inner leaflet to the outer leaflet in apoptosis, inducing phagocytosis of the soma. Recently, it has been recognized that phospholipids in the axonal membrane may be a signal for axonal degeneration, regeneration, or other processes. This review focuses on key recent developments and areas for ongoing investigations. KEY FACTS: Phosphatidylserine externalization propagates along an axon after axonal injury and is delayed in the Wallerian degeneration slow (Wld S ) mutant. The ATP8A2 flippase mutant has spontaneous axonal degeneration. Microdomains of axonal degeneration in spheroid bodies have differential externalization of phosphatidylserine and phosphatidylethanolamine. Phospholipid trafficking could represent a mechanism for coordinated axonal degeneration and elimination, i.e. axoptosis, analogous to apoptosis of the cell body.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
