Endocytosis of Coacervates into Liposomes.

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Abstrakt

Tytuł:: Endocytosis of Coacervates into Liposomes.
Autorzy:: Lu T; Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands.
Liese S; Institute of Physics, University of Augsburg, Universitätsstraße 1, 86159 Augsburg, Germany.
Schoenmakers L; Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands.
Weber CA; Institute of Physics, University of Augsburg, Universitätsstraße 1, 86159 Augsburg, Germany.
Suzuki H; Department of Precision Mechanics, Faculty of Science and Engineering, Chuo University, Tokyo 112-8551, Japan.
Huck WTS; Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands.
Spruijt E; Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands.
Źródło:: Journal of the American Chemical Society [J Am Chem Soc] 2022 Aug 03; Vol. 144 (30), pp. 13451-13455. Date of Electronic Publication: 2022 Jul 25.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: Washington, DC : American Chemical Society
Original Publication: Easton, Pa. [etc.]
MeSH Terms:: Endocytosis*
Liposomes*
Cell Membrane ; Wettability
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Substance Nomenclature:: 0 (Liposomes)
Entry Date(s):: Date Created: 20220725 Date Completed: 20220804 Latest Revision: 20220901
Update Code:: 20240105
PubMed Central ID:: PMC9354246
DOI:: 10.1021/jacs.2c04096
PMID:: 35878395
: Czasopismo naukowe

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Recent studies have shown that the interactions between condensates and biological membranes are of functional importance. Here, we study how the interaction between complex coacervates and liposomes as model systems can lead to wetting, membrane deformation, and endocytosis. Depending on the interaction strength between coacervates and liposomes, the wetting behavior ranged from nonwetting to engulfment (endocytosis) and complete wetting. Endocytosis of coacervates was found to be a general phenomenon: coacervates made from a wide range of components could be taken up by liposomes. A simple theory taking into account surface energies and coacervate sizes can explain the observed morphologies. Our findings can help to better understand condensate-membrane interactions in cellular systems and provide new avenues for intracellular delivery using coacervates.

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