-
Tytuł:
-
Transcription and genome integrity.
-
Autorzy:
-
Ljungman M; Departments of Radiation Oncology and Environmental Health Sciences, Rogel Cancer Center and Center for RNA Biomedicine, University of Michigan, Ann Arbor, MI, USA. Electronic address: .
-
Źródło:
-
DNA repair [DNA Repair (Amst)] 2022 Oct; Vol. 118, pp. 103373. Date of Electronic Publication: 2022 Jul 19.
-
Typ publikacji:
-
Journal Article; Research Support, N.I.H., Extramural
-
Język:
-
English
-
Imprint Name(s):
-
Original Publication: Amsterdam ; New York : Elsevier, c2002-
-
MeSH Terms:
-
DNA Repair*
Transcription, Genetic*
DNA/metabolism ; DNA Damage ; Genomic Instability ; Humans
-
Grant Information:
-
R01 CA213214 United States CA NCI NIH HHS
-
Contributed Indexing:
-
Keywords: DNA damage response; Landscape of transcription; R-loops; Splicing-uncoupled transcription; Transcription-coupled repair
-
Substance Nomenclature:
-
9007-49-2 (DNA)
-
Entry Date(s):
-
Date Created: 20220801 Date Completed: 20220909 Latest Revision: 20220921
-
Update Code:
-
20240105
-
DOI:
-
10.1016/j.dnarep.2022.103373
-
PMID:
-
35914488
-
Transcription can cause genome instability by promoting R-loop formation but also act as a mutation-suppressing machinery by sensing of DNA lesions leading to the activation of DNA damage signaling and transcription-coupled repair. Recovery of RNA synthesis following the resolution of repair of transcription-blocking lesions is critical to avoid apoptosis and several new factors involved in this process have recently been identified. Some DNA repair proteins are recruited to initiating RNA polymerases and this may expediate the recruitment of other factors that participate in the repair of transcription-blocking DNA lesions. Recent studies have shown that transcription of protein-coding genes does not always give rise to spliced transcripts, opening the possibility that cells may use the transcription machinery in a splicing-uncoupled manner for other purposes including surveillance of the transcribed genome.
Competing Interests: Conflict of interests I hereby declare that I do not have any conflicts of interests regarding this manuscript.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
