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Tytuł:
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Incidence and risk factors of preoperative deep vein thrombosis in patients with intertrochanteric fractures: a retrospective study.
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Autorzy:
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Song K; State Key Laboratory of Pharmaceutical Biotechnology, Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, People's Republic of China.; Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing, 210093, Jiangsu, People's Republic of China.
Zhu B; State Key Laboratory of Pharmaceutical Biotechnology, Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, People's Republic of China.; Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing, 210093, Jiangsu, People's Republic of China.
Yao Y; State Key Laboratory of Pharmaceutical Biotechnology, Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, People's Republic of China.; Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing, 210093, Jiangsu, People's Republic of China.
Jiang Q; State Key Laboratory of Pharmaceutical Biotechnology, Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, People's Republic of China.; Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing, 210093, Jiangsu, People's Republic of China.
Xiong J; Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, People's Republic of China.
Shi H; Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, People's Republic of China. .
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Źródło:
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Journal of orthopaedic surgery and research [J Orthop Surg Res] 2022 Aug 03; Vol. 17 (1), pp. 375. Date of Electronic Publication: 2022 Aug 03.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: London : BioMed Central, 2006-
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MeSH Terms:
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Hip Fractures*/complications
Venous Thromboembolism*
Venous Thrombosis*/diagnostic imaging
Venous Thrombosis*/epidemiology
Venous Thrombosis*/etiology
Anticoagulants/therapeutic use ; Female ; Humans ; Incidence ; Retrospective Studies ; Risk Factors
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References:
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Grant Information:
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BE2016608 jiangsu provincial key research and development foundation; 81702151 national natural science foundation of china; 81401793 national natural science foundation of china; 81572132 national natural science foundation of china; BK20170121 natural science foundation of jiangsu province; 021414380306 fundamental research funds for the central universities; 2016-WSW-060 six talent peaks project in jiangsu province; QRX17007 key project supported by medical science and technology development foundation, nanjing department of health
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Contributed Indexing:
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Keywords: Deep vein thrombosis; Epidemiology; Intertrochanteric fracture; Risk factors
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Substance Nomenclature:
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0 (Anticoagulants)
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Entry Date(s):
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Date Created: 20220803 Date Completed: 20220805 Latest Revision: 20220807
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Update Code:
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20240104
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PubMed Central ID:
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PMC9351110
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DOI:
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10.1186/s13018-022-03268-1
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PMID:
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35922845
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Background: The risk of perioperative complications remains high in patients with intertrochanteric fractures. Immobilization after injury may predispose these patients to deep vein thrombosis (DVT) while waiting for surgery. The aims of this study were to determine the incidence of preoperative DVT in patients with intertrochanteric fractures and identify independent risk factors.
Methods: This retrospective study included patients with intertrochanteric fractures waiting for surgical interventions at our institution from June 2018 to December 2020. All patients received pharmacologic thromboprophylaxis after admission and ultrasound screening for DVT in both lower limbs before surgery. Demographic, clinical and laboratory data of these patients were collected to perform univariate analysis first. Subsequently, factors with a significant difference in univariate analysis were introduced into the multivariate logistic regression analysis to determine the independent risk factors for preoperative DVT.
Results: A total of 266 patients were enrolled in this study. Seventy-one patients (26.7%) developed DVTs before surgery. The majority of DVTs were distal types (91.5%). There were 40 patients with DVTs only in the affected limb, 7 patients with DVTs only in the unaffected limb, and 24 patients with DVTs in both lower limbs. Advanced age, female, prolonged period from injury to admission, combined cranial trauma, shorter thrombin time, increased level of D-dimer and lower level of albumin proved to be the independent risk factors for preoperative DVT.
Conclusions: We observed a high incidence of preoperative DVT in patients with intertrochanteric fractures. Identification of patients at high risk may improve the prevention and treatment of preoperative DVT in this population.
(© 2022. The Author(s).)
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