Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Tytuł pozycji:

Influence of Peroxisome Proliferator-Activated Receptor (PPAR)-gamma Coactivator (PGC)-1 alpha gene rs8192678 polymorphism by gender on different health-related parameters in healthy young adults.

Tytuł:
Influence of Peroxisome Proliferator-Activated Receptor (PPAR)-gamma Coactivator (PGC)-1 alpha gene rs8192678 polymorphism by gender on different health-related parameters in healthy young adults.
Autorzy:
Montes-de-Oca-García A; MOVE-IT Research Group, Department of Physical Education, Faculty of Education Sciences, University of Cadiz, Cádiz, Spain.; Research Unit, Biomedical Research and Innovation Institute of Cadiz (INiBICA), Puerta Del Mar University Hospital, University of Cadiz, Cádiz, Spain.
Corral-Pérez J; MOVE-IT Research Group, Department of Physical Education, Faculty of Education Sciences, University of Cadiz, Cádiz, Spain.; Research Unit, Biomedical Research and Innovation Institute of Cadiz (INiBICA), Puerta Del Mar University Hospital, University of Cadiz, Cádiz, Spain.
Velázquez-Díaz D; MOVE-IT Research Group, Department of Physical Education, Faculty of Education Sciences, University of Cadiz, Cádiz, Spain.; Research Unit, Biomedical Research and Innovation Institute of Cadiz (INiBICA), Puerta Del Mar University Hospital, University of Cadiz, Cádiz, Spain.; Department of Psychology, Brain Aging and Cognitive Health Laboratory, University of Pittsburgh, Pittsburgh, PA, United States.
Perez-Bey A; Research Unit, Biomedical Research and Innovation Institute of Cadiz (INiBICA), Puerta Del Mar University Hospital, University of Cadiz, Cádiz, Spain.; Department of Physical Education, GALENO Research Group, Faculty of Education Sciences, University of Cadiz, Cádiz, Spain.
Rebollo-Ramos M; MOVE-IT Research Group, Department of Physical Education, Faculty of Education Sciences, University of Cadiz, Cádiz, Spain.; Research Unit, Biomedical Research and Innovation Institute of Cadiz (INiBICA), Puerta Del Mar University Hospital, University of Cadiz, Cádiz, Spain.
Marín-Galindo A; MOVE-IT Research Group, Department of Physical Education, Faculty of Education Sciences, University of Cadiz, Cádiz, Spain.; Research Unit, Biomedical Research and Innovation Institute of Cadiz (INiBICA), Puerta Del Mar University Hospital, University of Cadiz, Cádiz, Spain.
Gómez-Gallego F; Faculty of Health Sciences, International University of La Rioja, Logroño, Spain.
Calderon-Dominguez M; Research Unit, Biomedical Research and Innovation Institute of Cadiz (INiBICA), Puerta Del Mar University Hospital, University of Cadiz, Cádiz, Spain.; Biomedicine, Biotechnology and Public Health Department, University of Cadiz, Cádiz, Spain.
Casals C; MOVE-IT Research Group, Department of Physical Education, Faculty of Education Sciences, University of Cadiz, Cádiz, Spain.; Research Unit, Biomedical Research and Innovation Institute of Cadiz (INiBICA), Puerta Del Mar University Hospital, University of Cadiz, Cádiz, Spain.
Ponce-González JG; MOVE-IT Research Group, Department of Physical Education, Faculty of Education Sciences, University of Cadiz, Cádiz, Spain.; Research Unit, Biomedical Research and Innovation Institute of Cadiz (INiBICA), Puerta Del Mar University Hospital, University of Cadiz, Cádiz, Spain.
Źródło:
Frontiers in physiology [Front Physiol] 2022 Jul 22; Vol. 13, pp. 885185. Date of Electronic Publication: 2022 Jul 22 (Print Publication: 2022).
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: Lausanne : Frontiers Research Foundation
References:
Int J Mol Sci. 2018 May 15;19(5):. (PMID: 29762540)
Oncotarget. 2017 Aug 16;8(44):77000-77008. (PMID: 29100364)
Nat Rev Endocrinol. 2021 Jan;17(1):47-66. (PMID: 33173188)
Endocrinol Diabetes Nutr (Engl Ed). 2020 Feb;67(2):113-121. (PMID: 31204279)
J Clin Invest. 2020 Jun 1;130(6):3305-3314. (PMID: 32191646)
J Appl Physiol (1985). 2008 Oct;105(4):1352-8. (PMID: 18467552)
Nutrients. 2020 Sep 27;12(10):. (PMID: 32992649)
Genes Nutr. 2014 Jul;9(4):415. (PMID: 24996771)
Diabetologia. 2014 Mar;57(3):485-90. (PMID: 24317794)
Compr Physiol. 2017 Mar 16;7(2):635-674. (PMID: 28333384)
Appl Physiol Nutr Metab. 2018 Dec;43(12):1321-1325. (PMID: 29879371)
Eur J Sport Sci. 2021 Aug 13;:1-10. (PMID: 34304714)
Int J Exerc Sci. 2010 Jan 15;3(1):25-35. (PMID: 27182324)
Diabetes. 2003 Mar;52(3):895-8. (PMID: 12606537)
Int J Obes (Lond). 2020 Sep;44(9):1851-1858. (PMID: 32404950)
Eur J Sport Sci. 2021 Jun;21(6):907-917. (PMID: 32580645)
Adv Physiol Educ. 2006 Dec;30(4):145-51. (PMID: 17108241)
J Am Diet Assoc. 2006 Jun;106(6):881-903. (PMID: 16720129)
J Endocrinol. 2016 Jun;229(3):R99-R115. (PMID: 27094040)
Biomed Res Int. 2015;2015:285491. (PMID: 26185753)
Int J Environ Res Public Health. 2021 Mar 26;18(7):. (PMID: 33810312)
Acta Endocrinol (Buchar). 2017 Apr-Jun;13(2):161-167. (PMID: 31149168)
Nutrients. 2020 Oct 07;12(10):. (PMID: 33036360)
Diabetes Metab Res Rev. 2011 Feb;27(2):177-84. (PMID: 21294239)
Asia Pac J Public Health. 2015 Mar;27(2):NP544-51. (PMID: 23449621)
Mol Genet Metab. 2005 Sep-Oct;86(1-2):300-6. (PMID: 16122961)
Cell Metab. 2017 May 2;25(5):1027-1036. (PMID: 28467922)
J Clin Hypertens (Greenwich). 2013 Mar;15(3):162-70. (PMID: 23458587)
J Appl Physiol Respir Environ Exerc Physiol. 1983 Aug;55(2):628-34. (PMID: 6618956)
PLoS One. 2019 Jan 9;14(1):e0200967. (PMID: 30625151)
Med Sci Sports Exerc. 2002 Jan;34(1):92-7. (PMID: 11782653)
J Nutrigenet Nutrigenomics. 2012;5(2):59-71. (PMID: 22652814)
Med Sci Sports Exerc. 2017 Jan;49(1):133-140. (PMID: 27580144)
Prim Care Diabetes. 2018 Oct;12(5):416-424. (PMID: 30041843)
J Diabetes Sci Technol. 2019 May;13(3):597-600. (PMID: 30318910)
J Hum Hypertens. 2007 Sep;21(9):709-16. (PMID: 17443211)
PLoS One. 2015 Apr 17;10(4):e0123881. (PMID: 25886402)
Arq Bras Endocrinol Metabol. 2009 Mar;53(2):281-7. (PMID: 19466221)
Diabetes Metab Syndr. 2015 Jan-Mar;9(1):46-50. (PMID: 25450819)
Scand J Med Sci Sports. 2008 Apr;18(2):195-204. (PMID: 17490458)
Nutr Metab (Lond). 2010 Aug 25;7:68. (PMID: 20738843)
BMC Genet. 2018 Nov 29;19(1):107. (PMID: 30497374)
Diabetes Res Clin Pract. 2009 Dec;86(3):168-72. (PMID: 19828207)
Contributed Indexing:
Keywords: PPARGC1A; cardiometabolic risk; caucasian; genetic association studies; healthy lifestyle; metabolism; obesity; physical exercise
Entry Date(s):
Date Created: 20220808 Latest Revision: 20220809
Update Code:
20220908
PubMed Central ID:
PMC9354774
DOI:
10.3389/fphys.2022.885185
PMID:
35936915
Czasopismo naukowe
This study aimed to analyze the influence of the peroxisome proliferator-activated receptor (PPAR)-gamma coactivator (PGC)-1 alpha (PPARGC1A) gene rs8192678 C>T polymorphism on different health-related parameters in male and female young adults. The PPARGC1A gene rs8192678 polymorphism was ascertained by polymerase chain reaction in 74 healthy adults (28 women; 22.72 ± 4.40 years) from Andalusia (Spain). Health-related variables included cardiometabolic risk, anthropometry and body composition, biochemical parameters, insulin sensitivity (QUICKI and HOMA-IR indexes), blood pressure (BP) at rest and after exercise, diet, basal metabolism, physical activity, maximal fat oxidation, and cardiorespiratory fitness. Our results showed differences by PPARGC1A gene rs8192678 C>T polymorphism in body mass ( p = 0.002), body mass index ( p = 0.024), lean body mass ( p = 0.024), body fat ( p = 0.032), waist circumference ( p = 0.020), and BP recovery ratio ( p < 0.001). The recessive model (CC vs. CT/TT) showed similar results but also with differences in basal metabolism ( p = 0.045) and total energy expenditure ( p = 0.024). A genotype*sex interaction was found in the QUICKI index ( p = 0.016), with differences between CC and CT/TT in men ( p = 0.049) and between men and women inside the CT/TT group ( p = 0.049). Thus, the PPARGC1A gene rs8192678 C>T polymorphism is associated with body composition, basal metabolism, total energy expenditure, and BP recovery, where the CC genotype confers a protective effect. Moreover, our study highlighted sexual dimorphism in the influence of PPARGC1A gene rs8192678 C>T polymorphism on the QUICKI index.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Montes-de-Oca-García, Corral-Pérez, Velázquez-Díaz, Perez-Bey, Rebollo-Ramos, Marín-Galindo, Gómez-Gallego, Calderon-Dominguez, Casals and Ponce-González.)

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies

Prześlij opinię

Twoje opinie są dla nas bardzo ważne i mogą być niezwykle pomocne w pokazaniu nam, gdzie możemy dokonać ulepszeń. Bylibyśmy bardzo wdzięczni za poświęcenie kilku chwil na wypełnienie krótkiego formularza.

Formularz