Selenium and/or vitamin E upregulate the antioxidant gene expression and parameters in broilers.

Tytuł:: Selenium and/or vitamin E upregulate the antioxidant gene expression and parameters in broilers.
Autorzy:: Elgendey F; Genetics and Genetic Engineering, Department of Animal Wealth Development, Faculty of Veterinary Medicine, Benha University, Toukh, 13736, Egypt.
Al Wakeel RA; Department of Physiology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt.
Hemeda SA; Department of Animal Husbandry and Animal Wealth Development, Faculty of Veterinary Medicine, Alexandria University, Alexandria, 21526, Egypt.
Elshwash AM; Genetics and Genetic Engineering, Department of Animal Wealth Development, Faculty of Veterinary Medicine, Benha University, Toukh, 13736, Egypt.
Fadl SE; Biochemistry Department, Faculty of Veterinary Medicine, Matrouh University, Matrouh, 51744, Egypt. .
Abdelazim AM; Department of Basic Medical Sciences, College of Aapplied Medical Sciences, University of Bisha, Bisha, 61922, Saudi Arabia.
Alhujaily M; Department of Medical Laboratory Sciences, College of Applied Medical Sciences, University of Bisha, Bisha, 61922, Saudi Arabia.
Khalifa OA; Genetics and Genetic Engineering, Department of Animal Wealth Development, Faculty of Veterinary Medicine, Benha University, Toukh, 13736, Egypt.
Źródło:: BMC veterinary research [BMC Vet Res] 2022 Aug 13; Vol. 18 (1), pp. 310. Date of Electronic Publication: 2022 Aug 13.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: London : BioMed Central, 2005-
MeSH Terms:: Selenium*/pharmacology
Vitamin E*/pharmacology
Animals ; Antioxidants ; Chickens ; Copper/pharmacology ; Free Radicals ; Gene Expression ; Iron ; Sodium Selenite ; Vitamins
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Contributed Indexing:: Keywords: Antioxidants; Broilers; Copper and iron; Gene expression; Selenium; Vitamin E
Substance Nomenclature:: 0 (Antioxidants)
0 (Free Radicals)
0 (Vitamins)
1406-18-4 (Vitamin E)
789U1901C5 (Copper)
E1UOL152H7 (Iron)
H6241UJ22B (Selenium)
HIW548RQ3W (Sodium Selenite)
Entry Date(s):: Date Created: 20220813 Date Completed: 20220816 Latest Revision: 20230118
Update Code:: 20240104
PubMed Central ID:: PMC9375396
DOI:: 10.1186/s12917-022-03411-4
PMID:: 35964043
: Czasopismo naukowe

Pełny tekst

Background: In contrast to free radicals, the first line of protection is assumed to be vitamin E and selenium. The present protocol was designed to assess the roles of vitamin E and/or a selenium-rich diet that affected the blood iron and copper concentrations, liver tissue antioxidant and lipid peroxidation, and gene expression linked to antioxidants in the liver tissue of broilers. The young birds were classified according to the dietary supplement into four groups; control, vitamin E (100 mg Vitamin/kg diet), selenium (0.3 mg sodium selenite/kg diet), and vitamin E pulse selenium (100 mg vitamin/kg diet with 0.3 mg sodium selenite/kg diet) group.
Results: The results of this experiment suggested that the addition of vitamin E with selenium in the broiler diet significantly increased (P ≤ 0.05) serum iron when compared with the other groups and serum copper when compared with the vitamin E group. Moreover, the supplements (vitamin E or vitamin E with selenium) positively affected the enzymatic activity of the antioxidant-related enzymes with decreased malondialdehyde (MDA),which represents lipid peroxidation in broiler liver tissue. Moreover, the two supplements significantly upregulated genes expression related to antioxidants.
Conclusion: Therefore, vitamin E and/or selenium can not only act as exogenous antioxidants to prevent oxidative damage by scavenging free radicals and superoxide, but also act as gene regulators, regulating the expression of endogenous antioxidant enzymes.
(© 2022. The Author(s).)

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