Novel intrinsic factor Yun maintains female germline stem cell fate through Thickveins.

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Abstrakt

Tytuł:: Novel intrinsic factor Yun maintains female germline stem cell fate through Thickveins.
Autorzy:: Zhao H; College of Life Sciences, Capital Normal University, Beijing 100048, China.
Li Z; College of Life Sciences, Capital Normal University, Beijing 100048, China.
Kong R; College of Life Sciences, Capital Normal University, Beijing 100048, China.
Shi L; College of Life Sciences, Capital Normal University, Beijing 100048, China.
Ma R; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
Ren X; College of Life Sciences, Capital Normal University, Beijing 100048, China.
Li Z; College of Life Sciences, Capital Normal University, Beijing 100048, China. Electronic address: .
Źródło:: Stem cell reports [Stem Cell Reports] 2022 Sep 13; Vol. 17 (9), pp. 1914-1923. Date of Electronic Publication: 2022 Aug 18.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: [Cambridge, MA] : Cell Press, c 2013-
MeSH Terms:: Drosophila Proteins*/genetics
Drosophila Proteins*/metabolism
Oogonial Stem Cells*/metabolism
Animals ; Cell Differentiation/physiology ; Drosophila/metabolism ; Female ; Germ Cells ; Intrinsic Factor/metabolism ; Ovary/metabolism ; Protein Serine-Threonine Kinases ; Receptors, Cell Surface/metabolism
References:: Cell. 2008 Feb 22;132(4):598-611. (PMID: 18295578)
Curr Biol. 2012 Mar 20;22(6):515-21. (PMID: 22365848)
Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9304-9. (PMID: 19470484)
Chromosoma. 2018 Dec;127(4):489-504. (PMID: 30120539)
Development. 2004 May;131(9):1881-90. (PMID: 15105369)
Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11623-8. (PMID: 19556547)
Development. 2009 Nov;136(21):3627-35. (PMID: 19793889)
Cell Rep. 2015 Nov 17;13(7):1366-1379. (PMID: 26549449)
Nature. 2008 Sep 4;455(7209):72-7. (PMID: 18701888)
Nature. 2014 Oct 9;514(7521):233-6. (PMID: 25119050)
Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4633-8. (PMID: 12676994)
Wiley Interdiscip Rev Dev Biol. 2013 Mar-Apr;2(2):261-73. (PMID: 24009036)
Development. 2010 Aug 1;137(15):2461-9. (PMID: 20573703)
Stem Cell Reports. 2022 May 10;17(5):1120-1137. (PMID: 35427486)
Development. 1997 Sep;124(18):3651-62. (PMID: 9342057)
J Cell Biol. 2015 May 25;209(4):595-608. (PMID: 26008746)
Cell. 1998 Jul 24;94(2):251-60. (PMID: 9695953)
Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):. (PMID: 35115400)
Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14813-8. (PMID: 12393817)
J Genet Genomics. 2022 Mar;49(3):195-207. (PMID: 34547438)
J Cell Biol. 2008 Feb 25;180(4):721-8. (PMID: 18283115)
Sci Signal. 2010 Jul 27;3(132):ra57. (PMID: 20664066)
Development. 2004 Mar;131(6):1353-64. (PMID: 14973291)
Curr Opin Insect Sci. 2020 Feb;37:57-62. (PMID: 32120010)
PLoS One. 2014 Mar 21;9(3):e90267. (PMID: 24658126)
Dev Cell. 2005 Oct;9(4):501-10. (PMID: 16198292)
Development. 2004 Feb;131(4):703-12. (PMID: 14757636)
Genesis. 2011 Sep;49(9):698-718. (PMID: 21671348)
Curr Opin Genet Dev. 2011 Dec;21(6):684-9. (PMID: 21862315)
Cell Mol Life Sci. 2019 Nov;76(21):4309-4317. (PMID: 31300869)
Curr Biol. 2003 Oct 14;13(20):1786-91. (PMID: 14561403)
Development. 2004 Mar;131(6):1365-75. (PMID: 14973292)
Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19939-44. (PMID: 21041636)
Dev Cell. 2011 Jan 18;20(1):72-83. (PMID: 21238926)
Science. 2000 Oct 13;290(5490):328-30. (PMID: 11030649)
Genes Dev. 1990 Dec;4(12B):2242-51. (PMID: 2279698)
Dev Cell. 2009 Jul;17(1):123-33. (PMID: 19619497)
Development. 1995 Sep;121(9):2937-47. (PMID: 7555720)
J Cell Biol. 2009 Nov 16;187(4):473-80. (PMID: 19948496)
Cell. 2010 Dec 10;143(6):978-90. (PMID: 21145463)
Dev Cell. 2011 Jul 19;21(1):159-71. (PMID: 21763616)
J Cell Biol. 2008 Jan 28;180(2):257-60. (PMID: 18227277)
Development. 2005 Dec;132(24):5365-74. (PMID: 16280348)
Development. 1994 Apr;120(4):947-56. (PMID: 7600970)
PLoS One. 2013;8(3):e58301. (PMID: 23526974)
Curr Opin Insect Sci. 2020 Feb;37:1-7. (PMID: 31726320)
Cell Prolif. 2022 May;55(5):e13230. (PMID: 35437864)
Dev Biol. 2018 Jul 1;439(1):42-51. (PMID: 29679558)
Curr Biol. 2003 Dec 2;13(23):2065-72. (PMID: 14653996)
Sci Adv. 2020 May 13;6(20):eaaz0480. (PMID: 32426496)
EMBO Rep. 2011 Jun;12(6):519-26. (PMID: 21546910)
Contributed Indexing:: Keywords: BMP signaling; Drosophila; Germline stem cell; Tkv; Yun; niche; ovary
Substance Nomenclature:: 0 (Drosophila Proteins)
0 (Receptors, Cell Surface)
0 (dpp protein, Drosophila)
9008-12-2 (Intrinsic Factor)
EC 2.7.1.- (tkv protein, Drosophila)
EC 2.7.11.1 (Protein Serine-Threonine Kinases)
Entry Date(s):: Date Created: 20220819 Date Completed: 20220916 Latest Revision: 20221012
Update Code:: 20240104
PubMed Central ID:: PMC9481913
DOI:: 10.1016/j.stemcr.2022.07.014
PMID:: 35985332
: Czasopismo naukowe

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Germline stem cells (GSCs) are critical for the reproduction of an organism. The self-renewal and differentiation of GSCs must be tightly controlled to avoid uncontrolled stem cell proliferation or premature stem cell differentiation. However, how the self-renewal and differentiation of GSCs are properly controlled is not fully understood. Here, we find that the novel intrinsic factor Yun is required for female GSC maintenance in Drosophila. GSCs undergo precocious differentiation due to de-repression of differentiation factor Bam by defective BMP/Dpp signaling in the absence of yun. Mechanistically, Yun associates with and stabilizes Thickveins (Tkv), the type I receptor of Dpp/BMP signaling. Finally, ectopic expression of a constitutively active Tkv (Tkv QD ) completely suppresses GSC loss caused by yun depletion. Collectively, these data demonstrate that Yun functions through Tkv to maintain GSC fate. Our results provide new insight into the regulatory mechanisms of how stem cell maintenance is properly controlled.
Competing Interests: Conflicts of interest The authors declare no competing interests.
(Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.)

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