-
Tytuł:
-
Tannic acid post-treatment of enzymatically crosslinked chitosan-alginate hydrogels for biomedical applications.
-
Autorzy:
-
Jafari H; Université libre de Bruxelles (ULB), École polytechnique de Bruxelles, 3BIO-BioMatter, Avenue F.D. Roosevelt, 50 - CP 165/61, 1050 Brussels, Belgium. Electronic address: .
Ghaffari-Bohlouli P; Université libre de Bruxelles (ULB), École polytechnique de Bruxelles, 3BIO-BioMatter, Avenue F.D. Roosevelt, 50 - CP 165/61, 1050 Brussels, Belgium.
Podstawczyk D; Department of Process Engineering and Technology of Polymer and Carbon Materials, Faculty of Chemistry, Wroclaw University of Science and Technology, Norwida 4/6, Wroclaw 50-373, Poland.
Nie L; College of Life Sciences, Xinyang Normal University (XYNU), Xinyang 464000, China.
Shavandi A; Université libre de Bruxelles (ULB), École polytechnique de Bruxelles, 3BIO-BioMatter, Avenue F.D. Roosevelt, 50 - CP 165/61, 1050 Brussels, Belgium. Electronic address: .
-
Źródło:
-
Carbohydrate polymers [Carbohydr Polym] 2022 Nov 01; Vol. 295, pp. 119844. Date of Electronic Publication: 2022 Jul 09.
-
Typ publikacji:
-
Journal Article
-
Język:
-
English
-
Imprint Name(s):
-
Publication: <1992-> : Barking : Elsevier Applied Science Publishers
Original Publication: London [Eng.] : Applied Science Publishers, c1981-
-
MeSH Terms:
-
Chitosan*/chemistry
Hydrogels*/chemistry
Hydrogels*/pharmacology
Alginates/chemistry ; Antioxidants/chemistry ; Tannins/chemistry
-
Contributed Indexing:
-
Keywords: Adhesive hydrogels; Enzymatic crosslinking; Marine polysaccharides; Tannic acid treatment
-
Substance Nomenclature:
-
0 (Alginates)
0 (Antioxidants)
0 (Hydrogels)
0 (Tannins)
9012-76-4 (Chitosan)
-
Entry Date(s):
-
Date Created: 20220821 Date Completed: 20220823 Latest Revision: 20220823
-
Update Code:
-
20240104
-
DOI:
-
10.1016/j.carbpol.2022.119844
-
PMID:
-
35988997
-
Enzyme-mediated crosslinked hydrogels as soft materials for biomedical applications have gained considerable attention. In this article, we studied the effect of tannic acid post-treatment on adhesiveness and physiochemical properties of an enzymatically crosslinked hydrogel based on chitosan and alginate. The hydrogels were soaked in TA solution at different pH (3, 5.5, 7.4, and 9) and concentrations (1, 10, 20, 30 TA wt%). Increasing the TA concentration to 30 TA wt% and pH (up to 7.4) increased the TA loading and TA release. TA post-treatment reduced the swelling ratio and degradation rate of the hydrogels due to the formation of hydrogen bonding between TA molecules, chitosan, and alginate chains resulted in higher crosslinking density. TA-reinforced hydrogels with 30 % TA (Gel-TA 30) exhibited significantly high adhesive strength (up to 18 kPa), storage modulus (40 kPa), and antioxidant activity (>96 %), antibacterial activity, and proliferation and viability of 3 T3-L1 fibroblast cells.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)