Ambra1 in cancer: implications for clinical oncology.

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Abstrakt

Tytuł:: Ambra1 in cancer: implications for clinical oncology.
Autorzy:: Qin YQ; Department of Medical Oncology, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxuedong Road, Nanning, 530007, Guangxi, People's Republic of China.
Liu SY; Department of Medical Oncology, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxuedong Road, Nanning, 530007, Guangxi, People's Republic of China.
Lv ML; Department of Medical Oncology, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxuedong Road, Nanning, 530007, Guangxi, People's Republic of China.
Sun WL; Department of Medical Oncology, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxuedong Road, Nanning, 530007, Guangxi, People's Republic of China. .
Źródło:: Apoptosis : an international journal on programmed cell death [Apoptosis] 2022 Oct; Vol. 27 (9-10), pp. 720-729. Date of Electronic Publication: 2022 Aug 22.
Typ publikacji:: Journal Article; Review; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: 2005- : Dordrecht, Netherlands : Springer
Original Publication: London : Rapid Science Publishers,
MeSH Terms:: Adaptor Proteins, Signal Transducing*/metabolism
Apoptosis*/genetics
Autophagy/genetics ; Beclin-1/metabolism ; Carcinogenesis/genetics ; Humans ; Medical Oncology
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Contributed Indexing:: Keywords: Ambra1; Apoptosis; Autophagy; Cancer; Metastasis; Tumorigenesis
Substance Nomenclature:: 0 (AMBRA1 protein, human)
0 (Adaptor Proteins, Signal Transducing)
0 (Beclin-1)
Entry Date(s):: Date Created: 20220822 Date Completed: 20220920 Latest Revision: 20220923
Update Code:: 20240104
DOI:: 10.1007/s10495-022-01762-9
PMID:: 35994214
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Activating molecule in Beclin-1-regulated autophagy protein 1 (Ambra1) is well known to mediate the autophagy process and promote the formation of autophagosomes. In addition, Ambra1 is involved in the execution of apoptosis. A growing number of studies have revealed that this protein modifies the sensitivity of cancer cells to anticancer drugs by controlling the balance between autophagy and apoptosis. In addition, Ambra1 is a key factor in regulating the cell cycle, proliferation, invasion and migration. Therefore, it plays a key role in tumorigenesis and progression. Moreover, Ambra1 is highly expressed in a variety of cancers and is closely related to the prognosis of patients. Thus, it appears that Ambra1 has multiple roles in tumorigenesis and progression, which may have implications for clinical oncology. The present review focuses on recent advances in the study of Ambra1, especially the role of the protein in tumorigenesis, progression and effects on anticancer drug sensitivity.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

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