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Tytuł pozycji:

Enhancement of Tendon Repair Using Tendon-Derived Stem Cells in Small Intestinal Submucosa via M2 Macrophage Polarization.

Tytuł:
Enhancement of Tendon Repair Using Tendon-Derived Stem Cells in Small Intestinal Submucosa via M2 Macrophage Polarization.
Autorzy:
Mao X; Department of Orthopaedic Surgery, The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China.
Yao L; Department of Orthopaedic Surgery, The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China.
Li M; Zhejiang Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 315211, China.; Ningbo Medical Science Research Institute, Ningbo 315020, China.
Zhang X; Department of Orthopaedic Surgery, The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China.
Weng B; Zhejiang Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 315211, China.
Zhu W; Zhejiang Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 315211, China.
Ni R; Zhejiang Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 315211, China.
Chen K; Zhejiang Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 315211, China.
Yi L; Department of Orthopaedic Surgery, The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China.
Zhao J; Zhejiang Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 315211, China.
Mao H; Department of Orthopaedic Surgery, The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China.
Źródło:
Cells [Cells] 2022 Sep 05; Vol. 11 (17). Date of Electronic Publication: 2022 Sep 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Original Publication: Basel, Switzerland : MDPI
MeSH Terms:
Achilles Tendon*
Stem Cells*
Animals ; Cell Differentiation ; Macrophages ; Rats ; Rats, Sprague-Dawley
References:
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Contributed Indexing:
Keywords: Achilles tendon defects; small intestinal submucosa (SIS); tendon adhesion; tendon regeneration; tendon-derived stem cells (TDSCs); treatment
Entry Date(s):
Date Created: 20220909 Date Completed: 20220913 Latest Revision: 20221126
Update Code:
20240104
PubMed Central ID:
PMC9454771
DOI:
10.3390/cells11172770
PMID:
36078178
Czasopismo naukowe
(1) Background: Reconstruction of Achilles tendon defects and prevention of postoperative tendon adhesions were two serious clinical problems. In the treatment of Achilles tendon defects, decellularized matrix materials and mesenchymal stem cells (MSCs) were thought to address both problems. (2) Methods: In vitro, cell adhesion, proliferation, and tenogenic differentiation of tendon-derived stem cells (TDSCs) on small intestinal submucosa (SIS) were evaluated. RAW264.7 was induced by culture medium of TDSCs and TDSCs-SIS scaffold groups. A rat Achilles tendon defect model was used to assess effects on tendon regeneration and antiadhesion in vivo. (3) Results: SIS scaffold facilitated cell adhesion and tenogenic differentiation of TDSCs, while SIS hydrogel coating promoted proliferation of TDSCs. The expression of TGF-β and ARG-1 in the TDSCs-SIS scaffold group were higher than that in the TDSCs group on day 3 and 7. In vivo, the tendon regeneration and antiadhesion capacity of the implanted TDSCs-SIS scaffold was significantly enhanced. The expression of CD163 was significantly highest in the TDSCs-SIS scaffold group; meanwhile, the expression of CD68 decreased more significantly in the TDSCs-SIS scaffold group than the other two groups. (4) Conclusion: This study showed that biologically prepared SIS scaffolds synergistically promote tendon regeneration with TDSCs and achieve antiadhesion through M2 polarization of macrophages.
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