Tumor doubling time as preoperative predictor of malignancy and recurrence in newly diagnosed meningioma.

Szczegóły
Abstrakt

Tytuł:: Tumor doubling time as preoperative predictor of malignancy and recurrence in newly diagnosed meningioma.
Autorzy:: Miwa Y; Department of Neurosurgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Sugawara T; Department of Neurosurgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan. .
Kobayashi D; Department of Human Pathology, Tokyo Medical and Dental University, Tokyo, Japan.
Maehara T; Department of Neurosurgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Źródło:: Neurosurgical review [Neurosurg Rev] 2022 Dec; Vol. 45 (6), pp. 3683-3687. Date of Electronic Publication: 2022 Sep 22.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: Berlin : Springer Berlin Heidelberg
Original Publication: Berlin : Walter De Gruyter
MeSH Terms:: Meningeal Neoplasms*/diagnosis
Meningeal Neoplasms*/surgery
Meningeal Neoplasms*/pathology
Meningioma*/diagnosis
Meningioma*/surgery
Meningioma*/pathology
Humans ; Ki-67 Antigen/analysis ; Magnetic Resonance Imaging ; Neoplasm Recurrence, Local/surgery ; Neoplasm Recurrence, Local/pathology ; Prognosis ; Retrospective Studies ; Neoplasm Grading
References:: (2017) Report of Brain Tumor Registry of Japan (2005–2008). Neurol Med Chir (Tokyo) 57(Suppl 1):PS9–102. https://doi.org/10.2176/nmc.sup.2017-0001.
Agarwal V, McCutcheon BA, Hughes JD et al (2017) Trends in management of intracranial meningiomas: analysis of 49,921 cases from modern cohort. World Neurosurg 106:145–151. https://doi.org/10.1016/j.wneu.2017.06.127. (PMID: 10.1016/j.wneu.2017.06.12728666914)
Behbahani M, Skeie GO, Eide GE, Hausken A, Lund-Johansen M, Skeie BS (2019) A prospective study of the natural history of incidental meningioma—hold your horses! Neuro-Oncol Pract 6(6):438–450. https://doi.org/10.1093/nop/npz011. (PMID: 10.1093/nop/npz011)
Chamoun R, Krisht KM, Couldwell WT (2011) Incidental meningiomas. Neurosurg Focus 31(6):E19. https://doi.org/10.3171/2011.9.focus11220. (PMID: 10.3171/2011.9.focus1122022133182)
Chiba K, Sugawara T, Kobayashi D, Sato A, Murota Y, Maehara T (2021) Atypical histological features as risk factors for recurrence in newly diagnosed WHO grade I meningioma. Neurol Med Chir (Tokyo) 61(11):647–651. https://doi.org/10.2176/nmc.oa.2021-0153. (PMID: 10.2176/nmc.oa.2021-0153)
Hashiba T, Hashimoto N, Izumoto S et al (2009) Serial volumetric assessment of the natural history and growth pattern of incidentally discovered meningiomas. J Neurosug 110(4):675–684. https://doi.org/10.3171/2008.8.JNS08481. (PMID: 10.3171/2008.8.JNS08481)
Hashimoto N, Rabo CS, Okita Y et al (2012) Slower growth of skull base meningiomas compared with non-skull base meningiomas based on volumetric and biological studies. J Neurosurg 116(3):574–580. https://doi.org/10.3171/2011.11.jns11999. (PMID: 10.3171/2011.11.jns1199922175721)
Kakinuma K, Tanaka R, Onda K, Takahashi H (1998) Proliferative potential of recurrent intracranial meningiomas as evaluated by labelling indices of BUdR and Ki-67, and tumour doubling time. Acta Neurochir (Wien) 140(1):26–32. https://doi.org/10.1007/s007010050053. (PMID: 10.1007/s007010050053)
Kanda Y (2013) Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant 48(3):452–458. https://doi.org/10.1038/bmt.2012.244. (PMID: 10.1038/bmt.2012.24423208313)
Nakasu S, Nakasu Y, Nakajima M, Yokoyama M, Matsuda M, Handa J (1996) Potential doubling time and tumour doubling time in meningiomas and neurinomas. Acta Neurochir (Wien) 138(6):763–770. https://doi.org/10.1007/BF01411485. (PMID: 10.1007/BF01411485)
Nakasu S, Nakasu Y, Nakajima M, Yokoyama M, Matsuda M, Handa J (1996) Potential doubling time and tumour doubling time in meningiomas and neurinomas. Acta Neurochir 138(6):763–770. https://doi.org/10.1007/bf01411485. (PMID: 10.1007/bf014114858836295)
Nakasu S, Nakasu Y, Fukami T, Jito J, Nozaki K (2011) Growth curve analysis of asymptomatic and symptomatic meningiomas. J Neurooncol 102(2):303–310. https://doi.org/10.1007/s11060-010-0319-1. (PMID: 10.1007/s11060-010-0319-120686821)
Nakasu S, Onishi T, Kitahara S, Oowaki H, Matsumura KI (2019) CT Hounsfield unit is a good predictor of growth in meningiomas. Neurol Med Chir (Tokyo) 59(2):54–62. https://doi.org/10.2176/nmc.oa.2018-0209. (PMID: 10.2176/nmc.oa.2018-0209)
Nakasu S, Nakasu Y (2020) Natural history of meningiomas Review with meta-analyses. Neurol Med Chir (Tokyo) 60(3):109–120. https://doi.org/10.2176/nmc.ra.2019-0213. (PMID: 10.2176/nmc.ra.2019-0213)
Oya S, Kawai K, Nakatomi H, Saito N (2012) Significance of Simpson grading system in modern meningioma surgery: integration of the grade with MIB-1 labeling index as a key to predict the recurrence of WHO Grade I meningiomas. J Neurosurg 117(1):121–128. https://doi.org/10.3171/2012.3.JNS111945. (PMID: 10.3171/2012.3.JNS11194522559847)
Contributed Indexing:: Keywords: MIB-1 SI; Meningioma; Recurrence; Risk factor; Tumor doubling time
Substance Nomenclature:: 0 (Ki-67 Antigen)
Entry Date(s):: Date Created: 20220922 Date Completed: 20221121 Latest Revision: 20221121
Update Code:: 20240104
DOI:: 10.1007/s10143-022-01869-2
PMID:: 36136254
: Czasopismo naukowe

Full Text Finder

Most meningiomas are benign, and the indications for surgery are determined by size and symptoms, but some are malignant and have a high recurrence rate. Currently, no preoperative prognostic factors have been established. The purpose of this study was to investigate whether tumor doubling time (Td) is useful in predicting tumor prognosis. Patients who underwent surgery for newly diagnosed meningioma at our hospital between 2007 and 2021 with preoperative magnetic resonance (MR) imaging evaluation over a period of 6 months were included in this study. We calculated the Td from the preoperative MR images and examined the correlation between Td and WHO grade, MIB-1 SI, and other conditions. A total of 269 newly diagnosed meningiomas were operated on during the study period, of which 62 met inclusion criteria. The median Td was 1082 days (54-8579 days), and MIB-1 SI was 2.45% (0.7-14.6%). Td and MIB-1 SI had a negative correlation (r = - 0.319, p = 0.0122). MIB-1 SI was higher in patients with Td < 3 years than in those with Td ≥ 3 (p = 0.005), and the incidence of high WHO grade (grade2) was higher in patients with Td < 1 year than in patients with Td ≥ 1 (p = 0.014). Meningiomas with Td < 3 years had significantly higher MIB-1 SI, and tumors with Td < 1 year had a higher likelihood of malignancy. Therefore, early treatment should be considered in patients with short Td meningioma even if asymptomatic, and further consideration could be given to radical resection at the time of surgery.
(© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Informacja