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Tytuł pozycji:

Multiple Perspectives Reveal the Role of DNA Damage Repair Genes in the Molecular Classification and Prognosis of Pancreatic Adenocarcinoma.

Tytuł:
Multiple Perspectives Reveal the Role of DNA Damage Repair Genes in the Molecular Classification and Prognosis of Pancreatic Adenocarcinoma.
Autorzy:
Li Y; Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Zhang K; Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Peng L; Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Chen L; Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Gao H; Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Chen H; Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Sep 06; Vol. 23 (18). Date of Electronic Publication: 2022 Sep 06.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: Basel, Switzerland : MDPI, [2000-
MeSH Terms:
Adenocarcinoma*/genetics
Adenocarcinoma*/metabolism
Pancreatic Neoplasms*/diagnosis
Pancreatic Neoplasms*/genetics
Pancreatic Neoplasms*/metabolism
Biomarkers, Tumor/genetics ; DNA Damage/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Tumor Microenvironment/genetics ; Pancreatic Neoplasms
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Grant Information:
81973616 National Nature Science Foundation of China
Contributed Indexing:
Keywords: DNA damage repair; immune; molecular classification; pancreatic adenocarcinoma; prognosis
Substance Nomenclature:
0 (Biomarkers, Tumor)
Entry Date(s):
Date Created: 20220923 Date Completed: 20220926 Latest Revision: 20231213
Update Code:
20240104
PubMed Central ID:
PMC9499455
DOI:
10.3390/ijms231810231
PMID:
36142142
Czasopismo naukowe
Pancreatic adenocarcinoma (PAAD) is a highly heterogeneous and immunosuppressive cancer. This study investigated the diversity of DNA damage repair (DDR) and immune microenvironment in PAAD by transcriptomic and genomic analysis. Patients with PAAD were divided into two DDR-based subtypes with distinct prognosis and molecular characteristics. The differential expression genes were mostly enriched in DDR and immune-related pathways. In order to distinguish high- and low-risk groups clinically, a DDR- and immune-based 5-gene prognostic signature (termed DPRS) was established. Patients in the high-risk group had inferior prognosis, a low level of immune checkpoint gene expression and low sensitivity to DDR-associated inhibitors. Furthermore, single-cell sequencing was used to observe the performance of the DDR-based signature in a high dimension, and immunohistochemistry was used to verify the relationship between the genes we identified and the prognosis of patients with PAAD. In conclusion, the DDR heterogeneity of PAAD was demonstrated, and a novel DDR- and immune-based risk-scoring model was constructed, which indicated the feasibility of DPRS in predicting prognosis and drug response in PAAD patients.
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