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Tytuł:
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Understanding pathogen survival and transmission by arthropod vectors to prevent human disease.
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Autorzy:
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Barillas-Mury C; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Rockville, MD 20852, USA.
Ribeiro JMC; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Rockville, MD 20852, USA.
Valenzuela JG; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Rockville, MD 20852, USA.
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Źródło:
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Science (New York, N.Y.) [Science] 2022 Sep 30; Vol. 377 (6614), pp. eabc2757. Date of Electronic Publication: 2022 Sep 30.
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Typ publikacji:
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Journal Article; Review
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Język:
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English
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Imprint Name(s):
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Publication: : Washington, DC : American Association for the Advancement of Science
Original Publication: New York, N.Y. : [s.n.] 1880-
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MeSH Terms:
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Arthropod Vectors*/microbiology
Arthropod Vectors*/parasitology
Host-Pathogen Interactions*
Salivary Proteins and Peptides*/metabolism
Vector Borne Diseases*/prevention & control
Vector Borne Diseases*/transmission
Animals ; Humans ; Leishmaniasis/prevention & control ; Leishmaniasis/transmission ; Malaria/prevention & control ; Malaria/transmission
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Substance Nomenclature:
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0 (Salivary Proteins and Peptides)
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Entry Date(s):
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Date Created: 20220929 Date Completed: 20221003 Latest Revision: 20221019
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Update Code:
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20240105
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DOI:
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10.1126/science.abc2757
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PMID:
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36173836
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Many endemic poverty-associated diseases, such as malaria and leishmaniasis, are transmitted by arthropod vectors. Pathogens must interact with specific molecules in the vector gut, the microbiota, and the vector immune system to survive and be transmitted. The vertebrate host, in turn, is infected when the pathogen and vector-derived factors, such as salivary proteins, are delivered into the skin by a vector bite. Here, we review recent progress in our understanding of the biology of pathogen transmission from the human to the vector and back, from the vector to the host. We also highlight recent advances in the biology of vector-borne disease transmission, which have translated into additional strategies to prevent human disease by either reducing vector populations or by disrupting their ability to transmit pathogens.
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