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Tytuł pozycji:

Brain bioenergetics in chronic hypertension: Risk factor for acute ischemic stroke.

Tytuł:
Brain bioenergetics in chronic hypertension: Risk factor for acute ischemic stroke.
Autorzy:
Ferrari F; Department of Brain and Behavioural Sciences, School of Neurology - University of Pavia, Via Bassi 21, 27100 Pavia, Italy; Department of Biology and Biotechnology, University of Pavia, Via Ferrata 9, 27010 Pavia, Italy. Electronic address: .
Villa RF; Department of Biology and Biotechnology, University of Pavia, Via Ferrata 9, 27010 Pavia, Italy. Electronic address: .
Źródło:
Biochemical pharmacology [Biochem Pharmacol] 2022 Nov; Vol. 205, pp. 115260. Date of Electronic Publication: 2022 Sep 28.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Publication: Oxford : Elsevier Science
Original Publication: Oxford, New York [etc.] Paragamon Press.
MeSH Terms:
Ischemic Stroke*
Hypertension*/drug therapy
Brain Diseases*
Stroke*
Humans ; Cerebrovascular Circulation/physiology ; Brain ; Risk Factors ; Energy Metabolism
Contributed Indexing:
Keywords: Acute ischemic stroke; Brain bioenergetics; Cerebral autoregulation; Hypertension; Neurovascular coupling
Entry Date(s):
Date Created: 20220930 Date Completed: 20221020 Latest Revision: 20221129
Update Code:
20240105
DOI:
10.1016/j.bcp.2022.115260
PMID:
36179931
Czasopismo naukowe
Chronic hypertension is one of the key modifiable risk factors for acute ischemic stroke, also contributing to determine greater neurological deficits and worse functional outcome when an acute cerebrovascular event would occur. A tight relationship exists between cerebrovascular autoregulation, neuronal activity and brain bioenergetics. In chronic hypertension, progressive adaptations of these processes occur as an attempt to cope with the demanding necessity of brain functions, creating a new steady-state homeostatic condition. However, these adaptive modifications are insufficient to grant an adequate response to possible pathological perturbations of the established fragile hemodynamic and metabolic homeostasis. In this narrative review, we will discuss the main mechanisms by which alterations in brain bioenergetics and mitochondrial function in chronic hypertension could lead to increased risk of acute ischemic stroke, stressing the interconnections between hemodynamic factors (i.e. cerebral autoregulation and neurovascular coupling) and metabolic processes. Both experimental and clinical pieces of evidence will be discussed. Moreover, the potential role of mitochondrial dysfunction in determining, or at least sustaining, the pathogenesis and progression of chronic neurogenic hypertension will be considered. In the perspective of novel therapeutic strategies aiming at improving brain bioenergetics, we propose some determinant factors to consider in future studies focused on the cause-effect relationships between chronic hypertension and brain bioenergetic abnormalities (and vice versa), so to help translational research in this so-far unfilled gap.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Elsevier Inc. All rights reserved.)

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