High-resolution MRI to noninvasively characterize drainage around the carotid artery into the cervical lymph nodes.

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Abstrakt

Tytuł:: High-resolution MRI to noninvasively characterize drainage around the carotid artery into the cervical lymph nodes.
Autorzy:: Keser Z; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Smith G; Department of Radiology, College of Medicine, University of Florida, Gainesville, Florida, USA.
Cagil E; Department of Neurosurgery, Ankara Numune Training and Research Hospital, Ankara, Turkey.
Tufan F; Geriatrician (PP), Silivrikapi Mh. Hisaralti Cd, Istanbul, Turkey.
Albayram O; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.; Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina, USA.
Albayram MS; Department of Radiology, College of Medicine, University of Florida, Gainesville, Florida, USA.
Źródło:: Journal of neuroimaging : official journal of the American Society of Neuroimaging [J Neuroimaging] 2023 Jan; Vol. 33 (1), pp. 102-108. Date of Electronic Publication: 2022 Oct 02.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: 2009- : Hoboken, NJ : Wiley
Original Publication: Boston, Mass. : Little, Brown and Co., c1991-
MeSH Terms:: Lymph Nodes*
Magnetic Resonance Imaging*/methods
Male ; Female ; Humans ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Carotid Artery, Common ; Brain
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Contributed Indexing:: Keywords: brain; glymphatics; lymphatics; periarterial drainage
Entry Date(s):: Date Created: 20221003 Date Completed: 20230116 Latest Revision: 20230131
Update Code:: 20240105
DOI:: 10.1111/jon.13056
PMID:: 36184887
: Czasopismo naukowe

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Background and Purpose: Previous studies have proposed multiple parallel channels for waste clearance from the brain, though many gaps remain in our understanding of these systems. In this study, we examined periarterial fluid drainage around intracranial and extracranial segments of the internal carotid arteries (ICAs) from the brain into the cervical lymph nodes using a noninvasive and clinical-based method.
Methods: Eighty-one subjects (45 females, aged 15-80 years old) with nonlesioned epilepsy underwent high-resolution 3-dimensional T2-weighted fluid-attenuated inversion recovery (FLAIR) MRI. We utilized a noninvasive and clinical-based method with a manual semiautomated approach to characterize the periarterial lymphatic system's maximum thickness and signal intensities along the ICAs using high-resolution 3-dimensional FLAIR imaging. We conducted group comparisons and correlation analyses to investigate sex- and age-based trends. Results were corrected with Bonferroni's test for multiple comparisons, and we performed power analysis for sample size calculations.
Results: Using high-resolution FLAIR images, we show evidence that fluid drainage emerges around the ICA petrous segment and joins lymphatic flow from cranial nerves in the upper neck, with this flow ultimately draining into the cervical lymph nodes bilaterally. Lymphatic signal at the petrous segment level was significantly thinner in females compared to males bilaterally (w = 413, p = .0001 on the right, w = 356, p < .0001 on the left). Lymphatic drainage around the petrous segments of the ICAs bilaterally was thicker with age in males but not in females.
Conclusions: We describe the in vivo high-resolution imaging characteristics of periarterial fluid drainage along the vessel walls of ICAs. This represents a potentially major channel for brain waste clearance. We also report interesting sex- and age-based trends in these structures within our cohort.
(© 2022 American Society of Neuroimaging.)

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