Asthma exacerbations: the Achilles heel of asthma care.

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Abstrakt

Tytuł:: Asthma exacerbations: the Achilles heel of asthma care.
Autorzy:: McIntyre A; Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Busse WW; Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. Electronic address: .
Źródło:: Trends in molecular medicine [Trends Mol Med] 2022 Dec; Vol. 28 (12), pp. 1112-1127. Date of Electronic Publication: 2022 Oct 05.
Typ publikacji:: Journal Article; Review
Język:: English
Imprint Name(s):: Original Publication: Oxford, UK : Elsevier Science Ltd., c2001-
MeSH Terms:: Picornaviridae Infections*
Asthma*/therapy
Asthma*/drug therapy
Virus Diseases*/complications
Humans ; Rhinovirus/physiology ; Inflammation
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Grant Information:: T32 AI007635 United States AI NIAID NIH HHS
Contributed Indexing:: Keywords: T2 inflammation; airway inflammation; asthma exacerbations; biologics; rhinovirus infections
Entry Date(s):: Date Created: 20221008 Date Completed: 20221128 Latest Revision: 20230926
Update Code:: 20240105
PubMed Central ID:: PMC10519281
DOI:: 10.1016/j.molmed.2022.09.001
PMID:: 36208987
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Asthma exacerbations significantly impact millions of patients worldwide to pose large disease burdens on affected patients, families, and health-care systems. Although numerous environmental factors cause asthma exacerbations, viral respiratory infections are the principal triggers. Advances in the pathophysiology of asthma have elucidated dysregulated protective immune responses and upregulated inflammation that create susceptibility and risks for exacerbation. Biologics for the treatment of severe asthma reduce rates of exacerbations and identify specific pathways of inflammation that contribute to altered pathophysiology, novel therapeutic targets, and informative biomarkers. Major steps to prevent exacerbations include the identification of molecular pathways whose blockage will prevent asthma attacks safely, predictably, and effectively.
Competing Interests: Declaration of interests W.W.B. is a consultant for Sanofi, Regeneron, and GlaxoSmithKline.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)

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