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Tytuł:
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Conservative pattern of interaction of bat and human IgG antibodies with FcRn.
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Autorzy:
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Toshkova N; National Museum of Natural History, Bulgarian Academy of Sciences, 1 Tsar Osvoboditel Blvd., 1000, Sofia, Bulgaria; Institute of Biodiversity and Ecosystem Research, Bulgarian Academy of Sciences, 1 Tsar Osvoboditel Blvd., 1000, Sofia, Bulgaria. Electronic address: .
Zhelyazkova V; National Museum of Natural History, Bulgarian Academy of Sciences, 1 Tsar Osvoboditel Blvd., 1000, Sofia, Bulgaria; Centre de Recherche des Cordeliers, INSERM, CNRS, Sorbonne Université, Université de Paris, 75006, Paris, France.
Justesen S; Immunitrack Aps, Lersoe Park Alle 42, 2100, Copenhagen East, Denmark.
Dimitrov JD; Centre de Recherche des Cordeliers, INSERM, CNRS, Sorbonne Université, Université de Paris, 75006, Paris, France. Electronic address: .
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Źródło:
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Developmental and comparative immunology [Dev Comp Immunol] 2023 Feb; Vol. 139, pp. 104579. Date of Electronic Publication: 2022 Oct 20.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: Tarrytown Ny : Elsevier Science
Original Publication: Elmsford, N. Y., Pergamon Press., 1977-2004.
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MeSH Terms:
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Immunoglobulin G*
Mammals*
Humans ; Mice ; Animals
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Contributed Indexing:
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Keywords: Bat immunity; IgG; Immunoglobulins; Neonatal Fc receptor; Surface plasmon resonance
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Substance Nomenclature:
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0 (Immunoglobulin G)
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Entry Date(s):
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Date Created: 20221022 Date Completed: 20221215 Latest Revision: 20230213
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Update Code:
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20240105
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DOI:
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10.1016/j.dci.2022.104579
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PMID:
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36272453
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Recently, numerous studies report bats as reservoirs of emerging pathogens with little to no signs of infections. This is thought to be connected to the unique immune system of bats, which remains poorly characterized. Despite the physiological importance of the Neonatal Fc receptor (FcRn) in the homeostasis of IgG antibodies, it is unclear how its functional activity is evolutionary conservative among mammals, and so is the case for bats. Using surface plasmon resonance-based technology, we tested the interactions of IgG antibodies isolated from three bat species with recombinant human and mouse FcRn. Our data show that IgG from the studied bat species binds to both human and mouse FcRn, albeit with distinct affinities. Importantly, the binding pattern of bat IgG is similar to human IgG. This confirms the conservative nature of IgG-FcRn interaction and highlights the importance of FcRn IgG salvaging system in bats.
Competing Interests: Declaration of competing interest The authors have no conflicts of interest to declare.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
