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Tytuł:
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Early life exposure to triclosan from antimicrobial daily necessities may increase the potential risk of autism spectrum disorder: A multicenter study in China.
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Autorzy:
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Wu Q; Chongqing Key Laboratory of Childhood Nutrition and Health, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing, China.
Yang T; Chongqing Key Laboratory of Childhood Nutrition and Health, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing, China.
Chen L; Chongqing Key Laboratory of Childhood Nutrition and Health, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing, China.
Dai Y; Chongqing Key Laboratory of Childhood Nutrition and Health, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing, China.
Wei H; Chongqing Key Laboratory of Childhood Nutrition and Health, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing, China.
Jia F; Department of Developmental and Behavioral Pediatrics, the First Hospital of Jilin University, Changchun, China.
Hao Y; Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Li L; Department of Children Rehabilitation, Hainan Women and Children's Medical Center, Haikou, China.
Zhang J; Children Health Care Center, Xi'an Children's Hospital, Xi'an, China.
Wu L; Department of Children's and Adolescent Health, Public Health College of Harbin Medical University, Harbin, China.
Ke X; Child Mental Health Research Center of Nanjing Brain Hospital, Nanjing, China.
Yi M; Department of Child Health Care, the Affiliated Hospital of Qingdao University, Qingdao, China.
Hong Q; Maternal and Child Health Hospital of Baoan, Shenzhen, China.
Chen J; Department of Child Healthcare, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Fang S; Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Wang Y; NHC Key Laboratory of Birth Defect for Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, China.
Wang Q; Deyang Maternity & Child Healthcare Hospital, Deyang, Sichuan, China.
Jin C; Department of Children Health Care, Capital Institute of Pediatrics, Beijing, China.
Hu R; University of Chinese Academy of Sciences; State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China.
Chen J; Chongqing Key Laboratory of Childhood Nutrition and Health, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing, China.
Li T; Chongqing Key Laboratory of Childhood Nutrition and Health, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing, China. Electronic address: .
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Źródło:
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Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2022 Dec 01; Vol. 247, pp. 114197. Date of Electronic Publication: 2022 Oct 20.
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Typ publikacji:
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Multicenter Study; Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Amsterdam, Netherlands : Elsevier
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MeSH Terms:
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Autism Spectrum Disorder*/chemically induced
Autism Spectrum Disorder*/epidemiology
Triclosan*/toxicity
Endocrine Disruptors*/toxicity
Anti-Infective Agents*
Humans ; Child ; Pregnancy ; Female ; Male ; Rats ; Animals ; Child, Preschool ; Case-Control Studies ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Anti-Bacterial Agents
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Contributed Indexing:
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Keywords: Autism spectrum disorder; Core symptoms; Multicenter; Risk factor; Triclosan
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Substance Nomenclature:
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4NM5039Y5X (Triclosan)
0 (Endocrine Disruptors)
0 (Anti-Infective Agents)
0 (Anti-Bacterial Agents)
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Entry Date(s):
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Date Created: 20221024 Date Completed: 20221122 Latest Revision: 20221122
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Update Code:
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20240105
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DOI:
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10.1016/j.ecoenv.2022.114197
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PMID:
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36274318
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Background: Autism spectrum disorders (ASD) are a group of complex neurodevelopmental disorders with unclear etiologies. Our recent work indicated that maternal exposure to triclosan (TCS) significantly increased the autistic-like behavior in rats, possibly through disrupting neuronal retinoic acid signaling. Although environmental endocrine disruptors (EEDs) have been associated with autism in humans, the relationship between TCS, one of the EEDs found in antibacterial daily necessities, and autism has received little attention.
Objective: The aims of this multicenter study were to evaluate TCS concentrations in typically developing (TD) children and ASD children, and to determine the relationship between TCS levels and the core symptoms of ASD children.
Methods: A total of 1345 children with ASD and 1183 TD children were enrolled from 13 cities in China. Ages ranged between 2 and 7 years. A questionnaire was used to investigate the maternal use of antibacterial daily necessities (UADN) during pregnancy. The core symptoms of ASD were evaluated using the Autism Behavior Checklist (ABC), Childhood Autism Rating Scale (CARS), Social Response Scale (SRS), and the Children Neuropsychological and Behavior Scale-Revision 2016 (CNBS-R2016). The TCS concentration was measured using LC-MS/MS.
Results: Maternal UADN during pregnancy may be an unrecognized potential environmental risk factor for ASD (OR=1.267, P = 0.023). Maternal UADN during pregnancy strongly correlated with TCS levels in the offspring (Adjusted β = 0.277, P < 0.001). TCS concentration was higher in ASD children (P = 0.005), and positively correlated with ABC (Sensory subscales: P = 0.03; Social self-help subscales: P = 0.011) and SRS scale scores (Social awareness subscales: P = 0.045; Social communication subscales: P = 0.001; Autism behavior mannerisms subscales: P = 0.006; SRS total score: P = 0.003) in ASD children. This association was more pronounced in boys than in girls.
Conclusion: To our knowledge, this is the first case-control study to examine the correlation between TCS and ASD. Our results suggest that maternal UADN during pregnancy may be a potential risk of ASD in offspring. Further detection of TCS levels showed that maternal UADN during pregnancy may be associated with excessive TCS exposure. In addition, the level of TCS in children with ASD is higher than TD children. The higher levels of TCS in children with ASD may be significantly associated with more pronounced core symptoms, and this association was more significant in male children with ASD.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)
