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Tytuł:
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Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) positively regulates lipopolysaccharide-induced expression of CXC chemokine ligand 10 and 11 in mouse macrophages.
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Autorzy:
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Bandow K; Department of Diagnostic Sciences, Tufts University School of Dental Medicine, 136 Harrison Avenue, South Cove, Room 116, Boston, MA, 02111, USA; Division of Biochemistry, Department of Oral Biology and Tissue Engineering, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama, 350-0283, Japan. Electronic address: .
Smith A; Department of Diagnostic Sciences, Tufts University School of Dental Medicine, 136 Harrison Avenue, South Cove, Room 116, Boston, MA, 02111, USA.
Garlick J; Department of Diagnostic Sciences, Tufts University School of Dental Medicine, 136 Harrison Avenue, South Cove, Room 116, Boston, MA, 02111, USA.
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Źródło:
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Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2022 Dec 20; Vol. 635, pp. 227-235. Date of Electronic Publication: 2022 Oct 18.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: <2002- >: San Diego, CA : Elsevier
Original Publication: New York, Academic Press.
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MeSH Terms:
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Alzheimer Disease*/metabolism
Chemokines, CXC*/metabolism
Membrane Glycoproteins*/genetics
Membrane Glycoproteins*/metabolism
Receptors, Immunologic*/genetics
Receptors, Immunologic*/metabolism
Animals ; Mice ; Carrier Proteins/metabolism ; Ligands ; Lipopolysaccharides/metabolism ; Macrophages/metabolism ; Microglia/metabolism ; Osteoclasts/metabolism
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Contributed Indexing:
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Keywords: CXCL10; CXCL11; LPS; Macrophages; sTREM2
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Substance Nomenclature:
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0 (Carrier Proteins)
0 (Chemokines, CXC)
0 (Ligands)
0 (Lipopolysaccharides)
0 (Membrane Glycoproteins)
0 (Receptors, Immunologic)
0 (Trem2 protein, mouse)
0 (Cxcl10 protein, mouse)
0 (Cxcl11 protein, mouse)
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Entry Date(s):
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Date Created: 20221025 Date Completed: 20221116 Latest Revision: 20221208
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Update Code:
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20240105
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DOI:
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10.1016/j.bbrc.2022.10.048
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PMID:
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36283335
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TREM2 (Triggering receptor expressed on myeloid cells 2) is the causative gene for Nasu-Hakola disease, which is characterized by multiple bone cysts and leukoencephalopathy. In addition, mutations in this gene have been found to be correlated with the onset of Alzheimer's disease. TREM2 is an immunoreceptor expressed on dendritic cells, microglia, osteoclasts, and macrophages. TREM2 on the cell membrane is shed by some proteases and released as soluble TREM2 (sTREM2). Meanwhile, several TREM2 ligands have been reported, and lipopolysaccharide (LPS) is one of the candidates. Using RNA interference to examine TREM2-mediated LPS response in macrophages, we identified five chemokines whose expression was induced via TREM2. Furthermore, we showed that LPS-induced expression of CXC-motif chemokine ligand (Cxcl10) and Cxcl11 among the five chemokines was mediated in part through sTREM2. These results suggest that sTREM2 has cytokine-like functions in macrophages.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests Kenjiro Bandow reports financial support was provided by Japan Society for the Promotion of Science.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
