A novel pulsatile blood pump design for cardiothoracic surgery: Proof-of-concept in a mock circulation.

Tytuł:: A novel pulsatile blood pump design for cardiothoracic surgery: Proof-of-concept in a mock circulation.
Autorzy:: Weber E; Department of Cardiothoracic and Vascular Surgery, Ulm University Medical Center, Ulm, Germany.
Chong A; Triphasic Cardiac Pump Pty Ltd, Nedlands, Western Australia, Australia.
Liebold A; Department of Cardiothoracic and Vascular Surgery, Ulm University Medical Center, Ulm, Germany.
Hoenicka M; Department of Cardiothoracic and Vascular Surgery, Ulm University Medical Center, Ulm, Germany.
Źródło:: Artificial organs [Artif Organs] 2023 Mar; Vol. 47 (3), pp. 512-525. Date of Electronic Publication: 2022 Nov 12.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: Cambridge, MA : Wiley-Blackwell
Original Publication: Cleveland, International Society for Artificial Organs.
MeSH Terms:: Extracorporeal Circulation*
Hemodynamics*/physiology
Adult ; Humans ; Perfusion ; Blood Pressure ; Pulsatile Flow/physiology
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Weber E, Liebold A, Hoenicka M. A novel pulsatile blood pump design for cardiothoracic surgery-proof-of-concept in a mock circulation. Ulm: Universität Ulm; 2022. https://doi.org/10.18725/OPARU-42997.
Contributed Indexing:: Keywords: blood pump; extracorporeal circulation; pulsatile perfusion; surplus hemodynamic energy
Entry Date(s):: Date Created: 20221027 Date Completed: 20230314 Latest Revision: 20230314
Update Code:: 20240105
DOI:: 10.1111/aor.14436
PMID:: 36300590
: Czasopismo naukowe

Pełny tekst

Background: Pulsatile perfusion during extracorporeal circulation is a promising concept to improve perfusion of critical organs. Clinical benefits are limited by the amount of pulsatile energy provided by standard pumps. The present study investigated the properties of a novel positive displacement blood pump in a mock circulation.
Methods: The pump was attached to an aortic model with a human-like geometry and compliance as a pseudo patient. Hemodynamic data were recorded while the pump settings were adjusted systematically.
Results: Using a regular oxygenator, maximum flow was 2.6 L/min at a pressure of 27 mm Hg and a frequency (F) of 90 bpm. Pulse pressure (PP; 28.9 mm Hg) and surplus hemodynamic energy (SHE; 26.1% of mean arterial pressure) were highest at F = 40 bpm. Flow and pressure profiles appeared sinusoid. Using a low-resistance membrane ventilator to assess the impact of back pressure, maximum flow was 4.0 L/min at a pressure of 58.6 mm Hg and F = 40 bpm. At F = 40 bpm, PP was 58.7 mm Hg with an SHE of 33.4%. SHE decreased with increasing flow, heart rate, and systolic percentage but surpassed 10% with reasonable settings.
Conclusions: The present prototype achieved sufficient flow and pressure ranges only in the presence of a low-resistance membrane ventilator. It delivered supraphysiologic levels of pulse pressure and SHE. Further modifications are planned to establish this concept for adult pulsatile perfusion.
(© 2022 The Authors. Artificial Organs published by International Center for Artificial Organ and Transplantation (ICAOT) and Wiley Periodicals LLC.)

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