Early resource scarcity alters motivation for natural rewards in a sex- and reinforcer-dependent manner.

Tytuł:: Early resource scarcity alters motivation for natural rewards in a sex- and reinforcer-dependent manner.
Autorzy:: Williams AV; Department of Psychology and Neuroscience Program, Temple University, Philadelphia, PA, 19122, USA.
Flowers J; Department of Psychology and Neuroscience Program, Temple University, Philadelphia, PA, 19122, USA.
Coates KS; Department of Psychology and Neuroscience Program, Temple University, Philadelphia, PA, 19122, USA.
Ingram A; Department of Psychology and Neuroscience Program, Temple University, Philadelphia, PA, 19122, USA.
Hehn AT; Department of Psychology and Neuroscience Program, Temple University, Philadelphia, PA, 19122, USA.
Dupuis M; Department of Psychology and Neuroscience Program, Temple University, Philadelphia, PA, 19122, USA.
Wimmer ME; Department of Psychology and Neuroscience Program, Temple University, Philadelphia, PA, 19122, USA.
Venniro M; Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Bangasser DA; Department of Psychology and Neuroscience Program, Temple University, Philadelphia, PA, 19122, USA. .; Neuroscience Institute, Georgia State University, GA, 30303-5030, Atlanta, USA. .
Źródło:: Psychopharmacology [Psychopharmacology (Berl)] 2022 Dec; Vol. 239 (12), pp. 3929-3937. Date of Electronic Publication: 2022 Oct 27.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Berlin, New York, Springer-Verlag.
MeSH Terms:: Motivation*
Depressive Disorder, Major*
Female ; Male ; Rats ; Animals ; Rats, Long-Evans ; Reward ; Sucrose/pharmacology
References:: Behav Neurosci. 2004 Aug;118(4):730-9. (PMID: 15301600)
Biol Psychiatry. 2018 Jan 15;83(2):137-147. (PMID: 29033027)
PLoS One. 2016 Jun 28;11(6):e0158150. (PMID: 27351457)
Transl Psychiatry. 2022 Jun 16;12(1):251. (PMID: 35705547)
Soc Sci Med. 2015 Oct;143:36-44. (PMID: 26342911)
Neuroscience. 2005;135(3):959-68. (PMID: 16111825)
J Gerontol B Psychol Sci Soc Sci. 2019 Jan 1;74(1):95-104. (PMID: 29566242)
Horm Behav. 2019 May;111:46-59. (PMID: 30708031)
Neuropsychopharmacology. 2013 Aug;38(9):1685-97. (PMID: 23474592)
Neurotherapeutics. 2017 Jul;14(3):687-697. (PMID: 28324454)
Eur J Neurosci. 2020 Jul;52(1):2664-2680. (PMID: 31660665)
Brain Res Brain Res Protoc. 1997 May;1(2):203-9. (PMID: 9385085)
Transl Psychiatry. 2016 Oct 25;6(10):e930. (PMID: 27779623)
Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):. (PMID: 33593913)
Nat Neurosci. 2018 Nov;21(11):1520-1529. (PMID: 30323276)
Neuropsychopharmacology. 2012 Sep;37(10):2310-21. (PMID: 22669169)
Mol Psychiatry. 2021 Aug;26(8):4409-4416. (PMID: 31822817)
Biol Psychiatry. 2006 Jun 15;59(12):1151-9. (PMID: 16566899)
Biol Psychiatry. 2019 Dec 1;86(11):848-856. (PMID: 31326085)
Stress. 2017 Sep;20(5):421-448. (PMID: 28617197)
Int J Psychophysiol. 2015 Nov;98(2 Pt 2):227-239. (PMID: 25655926)
Transl Psychiatry. 2016 Jan 05;6:e702. (PMID: 26731439)
Neuropharmacology. 2021 May 1;188:108519. (PMID: 33711348)
Nat Protoc. 2020 Apr;15(4):1542-1559. (PMID: 32203485)
Neuropsychopharmacology. 2022 May;47(6):1231-1239. (PMID: 35102257)
Biol Psychiatry. 2022 Jun 1;91(11):988-997. (PMID: 35074211)
Dev Psychobiol. 2021 Sep;63(6):e22144. (PMID: 34053070)
J Am Acad Child Adolesc Psychiatry. 2020 Jul;59(7):842-855. (PMID: 31676392)
Biol Psychiatry. 2010 Jun 15;67(12):1137-45. (PMID: 20163787)
Neuropsychopharmacology. 2022 Jun;47(7):1285-1291. (PMID: 35338255)
Neuroscience. 2008 Jun 26;154(3):1132-42. (PMID: 18501521)
PLoS One. 2019 Mar 13;14(3):e0213700. (PMID: 30865713)
Nat Rev Neurosci. 2013 Sep;14(9):609-25. (PMID: 23942470)
Dev Psychobiol. 1981 Mar;14(2):169-71. (PMID: 7202855)
J Neurochem. 2021 Jun;157(5):1450-1472. (PMID: 33420731)
Neuropsychopharmacology. 2023 Jan;48(1):79-89. (PMID: 35701550)
Neurobiol Stress. 2018 Jan 12;8:57-67. (PMID: 29888304)
Pharmacol Biochem Behav. 1993 Jul;45(3):539-48. (PMID: 8332614)
Front Behav Neurosci. 2019 Jul 25;13:167. (PMID: 31402857)
Curr Dir Psychol Sci. 2013 Jun 1;22(3):244-249. (PMID: 24748727)
Rev Neurosci. 2018 Sep 25;29(7):727-744. (PMID: 29573379)
Neurobiol Stress. 2021 Oct 16;15:100409. (PMID: 34746338)
Am Psychol. 2004 Feb-Mar;59(2):77-92. (PMID: 14992634)
Grant Information:: DA047976 United States DA NIDA NIH HHS; DP1 DA046537 United States DA NIDA NIH HHS; T32 DA007237 United States DA NIDA NIH HHS; DA049837 United States DA NIDA NIH HHS; DA056534 United States DA NIDA NIH HHS; DA007237 United States DA NIDA NIH HHS; R01 DA056534 United States DA NIDA NIH HHS; R01 DA049837 United States DA NIDA NIH HHS; R00 DA047976 United States DA NIDA NIH HHS
Contributed Indexing:: Keywords: Early life stress; Food reward; LBN; Natural reward; Sex difference; Social motivation
Substance Nomenclature:: 57-50-1 (Sucrose)
Entry Date(s):: Date Created: 20221027 Date Completed: 20221121 Latest Revision: 20231202
Update Code:: 20240105
DOI:: 10.1007/s00213-022-06264-9
PMID:: 36301314
: Czasopismo naukowe

Pełny tekst

Rationale: Early life adversity impacts reward-related behaviors, including reward seeking for drugs of abuse. However, the effects of early stress on natural rewards, such as food and social rewards, which have strong implications for symptoms of psychiatric conditions such as major depressive disorder (MDD), are understudied. To fill this gap, we used the limited bedding and nesting (LBN) procedure to assess the impact of early resource scarcity on motivational drive for both food and social rewards in rats.
Methods: Male and female Long Evans rats were reared in either an LBN environment, with limited nesting materials and no enrichment, from their postnatal day 2-9 or control environment with ample nesting materials and enrichment. As adults, they were tested for reward-seeking behavior on progressive ratio operant tasks: food reward (sucrose) or social reward (access to a same-sex/age conspecific).
Results: We observed sex differences in the impact of LBN on motivation for natural rewards. In males, LBN increased motivation for both a sucrose and social reward. In females, LBN reduced motivation for sucrose but had no effect on social reward.
Conclusions: These results suggest that the effects of LBN on motivation for natural rewards are both sex- and reinforcer-dependent, with males and females showing differential motivation for food and social rewards following early scarcity. Our previous data revealed an LBN-driven reduction in motivation for morphine in males and no effect in females, highlighting the reinforcer-dependent impact of early resource scarcity on motivated behavior more widely.
(© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

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