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Tytuł:
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Acquired reactive perforating collagenosis, a rare entity at uncommon site.
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Autorzy:
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Ambalathinkal JJ; Department of Dermatology, MGM Medical College, Kamothe, Navi Mumbai, Maharashtra, India.
Phiske MM; Department of Dermatology, MGM Medical College, Kamothe, Navi Mumbai, Maharashtra, India.
Someshwar SJ; Department of Dermatology, MGM Medical College, Kamothe, Navi Mumbai, Maharashtra, India.
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Źródło:
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Indian journal of pathology & microbiology [Indian J Pathol Microbiol] 2022 Oct-Dec; Vol. 65 (4), pp. 895-897.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Mumbai : Medknow
Original Publication: Chandigarh : Indian Association of Pathologists & Microbiologists.
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MeSH Terms:
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Collagen Diseases*/diagnosis
Collagen Diseases*/pathology
Skin Diseases*/diagnosis
Skin Diseases*/etiology
Skin Diseases*/pathology
Diabetes Mellitus*
Adult ; Humans ; Female ; Middle Aged ; Epidermis/pathology ; Collagen
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Contributed Indexing:
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Keywords: Back; diabetes mellitus; reactive perforating collagenosis
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Substance Nomenclature:
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9007-34-5 (Collagen)
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Entry Date(s):
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Date Created: 20221029 Date Completed: 20221101 Latest Revision: 20221101
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Update Code:
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20240105
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DOI:
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10.4103/ijpm.ijpm_333_21
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PMID:
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36308201
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Acquired reactive perforating collagenosis (ARPC), rare disorder characterized by transepidermal elimination (TEE) of collagen fibers, is seen in adult diabetics. Genetic predisposition, familial aggregation, trauma, bites and scratching are implicated. Diabetics develop microvascular diseases leading to intense pruritus causing repeated micro trauma leading to necrosis of connective tissue of dermis, causing TEE. Isolated papules, plaques and nodules with central keratotic plugs, are mostly seen on extensor surfaces of limbs but trunk and face may be involved. Histopathology shows extrusion of abnormal collagen fibers through epidermis. Multiple treatment modalities show variable response. A 52 year old diabetic female had multiple, itchy, well defined, erythematous papules and plaques with central adherent crusting on lower back since 1 month. Histopathology showed cup shaped epidermal depression filled with plug of altered collagen, acanthotic epidermis with hyperkeratosis and parakeratosis. Underlying epidermis was thin with fine slits through which vertically oriented basophilic collagen fibers were extruded.
Competing Interests: None
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