Testicular aging, male fertility and beyond.

Szczegóły
Abstrakt

Tytuł:: Testicular aging, male fertility and beyond.
Autorzy:: Dong S; Institute of Reproductive Medicine, Medical School, Nantong University, Nantong, China.
Chen C; Institute of Reproductive Medicine, Medical School, Nantong University, Nantong, China.
Zhang J; Institute of Reproductive Medicine, Medical School, Nantong University, Nantong, China.
Gao Y; Laboratory Animal Center, Nantong University, Nantong, China.
Zeng X; Institute of Reproductive Medicine, Medical School, Nantong University, Nantong, China.
Zhang X; Institute of Reproductive Medicine, Medical School, Nantong University, Nantong, China.
Źródło:: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2022 Oct 13; Vol. 13, pp. 1012119. Date of Electronic Publication: 2022 Oct 13 (Print Publication: 2022).
Typ publikacji:: Journal Article; Review; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: [Lausanne : Frontiers Research Foundation]
MeSH Terms:: Testis*
Aging, Premature*/metabolism
Aging, Premature*/pathology
Male ; Humans ; Aged ; Semen ; Aging ; Fertility/genetics
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Contributed Indexing:: Keywords: aging-dependent infertility; male aging; sperm function; spermatogenesis; testicular premature aging
Entry Date(s):: Date Created: 20221031 Date Completed: 20221101 Latest Revision: 20231106
Update Code:: 20240105
PubMed Central ID:: PMC9606211
DOI:: 10.3389/fendo.2022.1012119
PMID:: 36313743
: Czasopismo naukowe

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Normal spermatogenesis and sperm function are crucial for male fertility. The effects of healthy testicular aging and testicular premature aging on spermatogenesis, sperm function, and the spermatogenesis microenvironment cannot be ignored. Compared with younger men, the testis of older men tends to have disturbed spermatogenic processes, sperm abnormalities, sperm dysfunction, and impaired Sertoli and Leydig cells, which ultimately results in male infertility. Various exogenous and endogenous factors also contribute to pathological testicular premature aging, such as adverse environmental stressors and gene mutations. Mechanistically, Y-chromosomal microdeletions, increase in telomere length and oxidative stress, accumulation of DNA damage with decreased repair ability, alterations in epigenetic modifications, miRNA and lncRNA expression abnormalities, have been associated with impaired male fertility due to aging. In recent years, the key molecules and signaling pathways that regulate testicular aging and premature aging have been identified, thereby providing new strategies for diagnosis and treatment. This review provides a comprehensive overview of the underlying mechanisms of aging on spermatogenesis. Furthermore, potential rescue measures for reproductive aging have been discussed. Finally, the inadequacy of testicular aging research and future directions for research have been envisaged to aid in the diagnosis and treatment of testicular aging and premature aging.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Dong, Chen, Zhang, Gao, Zeng and Zhang.)

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