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Tytuł pozycji:

The individuality paradigm: Automated longitudinal activity tracking of large cohorts of genetically identical mice in an enriched environment.

Tytuł:
The individuality paradigm: Automated longitudinal activity tracking of large cohorts of genetically identical mice in an enriched environment.
Autorzy:
Kempermann G; German Center for Neurodegenerative Diseases (DZNE) Dresden, Dresden, Germany; CRTD - Center for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany. Electronic address: .
Lopes JB; German Center for Neurodegenerative Diseases (DZNE) Dresden, Dresden, Germany; CRTD - Center for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany.
Zocher S; German Center for Neurodegenerative Diseases (DZNE) Dresden, Dresden, Germany; CRTD - Center for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany.
Schilling S; German Center for Neurodegenerative Diseases (DZNE) Dresden, Dresden, Germany; CRTD - Center for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany.
Ehret F; German Center for Neurodegenerative Diseases (DZNE) Dresden, Dresden, Germany; CRTD - Center for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany; Institute of Anatomy, TU Dresden, Dresden, Germany.
Garthe A; German Center for Neurodegenerative Diseases (DZNE) Dresden, Dresden, Germany; CRTD - Center for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany.
Karasinsky A; German Center for Neurodegenerative Diseases (DZNE) Dresden, Dresden, Germany; CRTD - Center for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany.
Brandmaier AM; Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany.
Lindenberger U; Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany.
Winter Y; Institute of Biology, Humboldt University, Berlin, Germany; Charité University Medicine, Berlin, Germany.
Overall RW; German Center for Neurodegenerative Diseases (DZNE) Dresden, Dresden, Germany; CRTD - Center for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany; Institute of Biology, Humboldt University, Berlin, Germany.
Źródło:
Neurobiology of disease [Neurobiol Dis] 2022 Dec; Vol. 175, pp. 105916. Date of Electronic Publication: 2022 Nov 04.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Publication: San Diego, CA : Academic Press
Original Publication: Oxford : Blackwell Science, c1994-
MeSH Terms:
Individuality*
Neuronal Plasticity*
Animals ; Mice
Contributed Indexing:
Keywords: Aging; Behavior; Brain; Environmental enrichment; Gene environment interaction; Home-cage tracking; Individuation; Longitudinal; Non-shared environment; Plasticity
Entry Date(s):
Date Created: 20221106 Date Completed: 20221216 Latest Revision: 20221222
Update Code:
20240105
DOI:
10.1016/j.nbd.2022.105916
PMID:
36336243
Czasopismo naukowe
Personalized medicine intensifies interest in experimental paradigms that delineate sources of phenotypic variation. The paradigm of environmental enrichment allows for comparisons among differently housed laboratory rodents to unravel environmental effects on brain plasticity and related phenotypes. We have developed a new longitudinal variant of this paradigm, which allows to investigate the emergence of individuality, the divergence of individual behavioral trajectories under a constant genetic background and in a shared environment. We here describe this novel method, the "Individuality Paradigm," which allows to investigate mechanisms that drive individuality. Various aspects of individual activity are tracked over time to identify the contribution of the non-shared environment, that is the extent to which the experience of an environment differs between individual members of a population. We describe the design of this paradigm in detail, lay out its scientific potential beyond the published studies and discuss how it differs from other approaches to study individuality. The custom-built cage system, commercially marketed as "ColonyRack", allows mice to roam freely between 70 cages through connector tubes equipped with ring antennas that detect each animal's ID from an RFID transponder implanted in the animal's neck. The system has a total floor area of 2.74 m 2 and its spatial resolution corresponds to the size of the individual cages. Spatiotemporally resolved antenna contacts yield longitudinal measures of individual behavior, including the powerful measure of roaming entropy (RE). The Individuality Paradigm provides a rodent model of the making of individuality and the impact of the 'non-shared' environment on life-course development.
Competing Interests: Declaration of Competing Interest YW is owner of PhenoSys, the manufacturer of the cage system presented in this article. The other authors declare no conflict of interest.
(Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)

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