No dynamic changes in the expression of genes related to the epigenetic mechanism during acute exercise.

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Tytuł:: No dynamic changes in the expression of genes related to the epigenetic mechanism during acute exercise.
Autorzy:: Światowy WJ; Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Święcickiego 6, 60-781, Poznan, Poland. .
Zieliński J; Department of Athletics Strength and Conditioning, Poznan University of Physical Education, Królowej Jadwigi 27/39, 61-871, Poznan, Poland.
Osielska MA; Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Święcickiego 6, 60-781, Poznan, Poland.
Kusy K; Department of Athletics Strength and Conditioning, Poznan University of Physical Education, Królowej Jadwigi 27/39, 61-871, Poznan, Poland.
Wieliński D; Department of Anthropology and Biometry, Poznan University of Physical Education, Krolowej Jadwigi 27/39, 61-871, Poznan, Poland.
Pławski A; Department of General, Endocrinological Surgery and Gastroenterological Oncology, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355, Poznan, Poland.; Institute of Human Genetics, Polish Academy of Sciences, Strzeszynska 32, 60-479, Poznan, Poland.
Jagodziński PP; Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Święcickiego 6, 60-781, Poznan, Poland. .
Źródło:: Journal of applied genetics [J Appl Genet] 2023 Feb; Vol. 64 (1), pp. 81-87. Date of Electronic Publication: 2022 Nov 10.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: 2011- : Cheshire, United Kingdom : Springer
Original Publication: Poznań, Poland : Institute of Plant Genetics, Polish Academy of Sciences, 1995-
MeSH Terms:: Leukocytes, Mononuclear*
Exercise*
Humans ; Epigenesis, Genetic ; RNA, Messenger
References:: J Musculoskelet Neuronal Interact. 2013 Jun;13(2):133-46. (PMID: 23728100)
Brain Plast. 2017 Mar 28;2(2):127-152. (PMID: 29765853)
Mol Genet Genomic Med. 2019 May;7(5):e651. (PMID: 30920174)
Nat Rev Genet. 2006 Sep;7(9):715-27. (PMID: 16983801)
Exerc Immunol Rev. 2006;12:6-33. (PMID: 17201070)
Curr Opin Cell Biol. 2001 Jun;13(3):263-73. (PMID: 11343896)
Cancer Genomics Proteomics. 2007 Nov-Dec;4(6):387-98. (PMID: 18204201)
Aging Cell. 2016 Aug;15(4):755-65. (PMID: 27169697)
Cells. 2019 Sep 25;8(10):. (PMID: 31557902)
Physiol Rep. 2015 Dec;3(12):. (PMID: 26660547)
PLoS One. 2011 Apr 05;6(4):e18571. (PMID: 21483668)
Drug Discov Today. 2014 Jul;19(7):1015-8. (PMID: 24632002)
Redox Biol. 2016 Dec;10:34-44. (PMID: 27687219)
Z Rheumatol. 2015 Dec;74(10):902-10. (PMID: 26347123)
Adv Exp Med Biol. 2020;1253:3-55. (PMID: 32445090)
BMC Genomics. 2017 Nov 14;18(Suppl 8):802. (PMID: 29143608)
J Trace Elem Med Biol. 2015 Jan;29:249-54. (PMID: 25240911)
Physiol Rep. 2015 Sep;3(9):. (PMID: 26359239)
Oxid Med Cell Longev. 2017;2017:1530230. (PMID: 29142617)
Am J Physiol Regul Integr Comp Physiol. 2017 Jul 1;313(1):R35-R43. (PMID: 28404582)
Epigenetics. 2019 Mar;14(3):294-309. (PMID: 30764736)
J Physiol. 1999 Feb 15;515 ( Pt 1):287-91. (PMID: 9925898)
Mediators Inflamm. 2015;2015:201703. (PMID: 25814785)
J Appl Physiol (1985). 2011 Jan;110(1):258-63. (PMID: 21030677)
Histochem Cell Biol. 2004 Apr;121(4):329-34. (PMID: 14997318)
PLoS One. 2014 Jan 14;9(1):e85276. (PMID: 24454832)
Redox Biol. 2020 Aug;35:101477. (PMID: 32127290)
EMBO J. 2001 Apr 2;20(7):1739-53. (PMID: 11285237)
J Physiol. 2009 Dec 15;587(Pt 24):5951-8. (PMID: 19884317)
Diabetes. 2004 May;53(5):1208-14. (PMID: 15111488)
Sports Med. 2001 Feb;31(2):115-44. (PMID: 11227979)
Cell Metab. 2012 Mar 7;15(3):405-11. (PMID: 22405075)
Rheumatol Int. 2017 May;37(5):775-783. (PMID: 28349196)
BMC Sports Sci Med Rehabil. 2022 Jan 6;14(1):5. (PMID: 34991697)
PLoS Genet. 2013 Jun;9(6):e1003572. (PMID: 23825961)
Grant Information:: 2013/09/B/NZ7/02556 Narodowe Centrum Nauki; 2647 Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu
Contributed Indexing:: Keywords: Acute exercise; DNA methylation; DNMT1; Epigenetic; HDAC1; JHDM1D
Substance Nomenclature:: 0 (RNA, Messenger)
Entry Date(s):: Date Created: 20221109 Date Completed: 20230116 Latest Revision: 20230116
Update Code:: 20240104
PubMed Central ID:: PMC9836983
DOI:: 10.1007/s13353-022-00736-6
PMID:: 36352208
: Czasopismo naukowe

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Physical exercise results in structural remodeling in tissues and modifies cellular metabolism. Changes in gene expression lie at the root of these adaptations. Epigenetic changes are one of the factors responsible for such exercise-related alterations. One-hour acute exercise will change DNMT1, HDAC1, and JHDM1D transcriptions in PBMC. This study examined changes in the expression of genes responsible for epigenetic modifications (HDAC1, DNMT1, and JHDM1D) during and after an incremental exercise test on a treadmill and a 30-min recovery. Blood samples from 9 highly trained triathletes were tested. Examination of the transcripts showed no significant changes. Correlations between transcript results and biochemical indices revealed a significant (p = 0.007) relationship between JHDM1D mRNA and the number of monocytes at peak exercise intensity (exhaustion), while there was no significant (p = 0.053) correlation at rest. There are no rapid changes in the mRNA levels of the genes studied in blood cells in competitive athletes during acute exercise and recovery. Due to the small group of subjects studied, more extensive research is needed to verify correlations between transcription and biochemical variables.
(© 2022. The Author(s).)

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