Penetration study of p-methoxycinnamic acid (PMCA) in nanostructured lipid carrier, solid lipid nanoparticles, and simple cream into the rat skin.

Tytuł:: Penetration study of p-methoxycinnamic acid (PMCA) in nanostructured lipid carrier, solid lipid nanoparticles, and simple cream into the rat skin.
Autorzy:: Rosita N; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia. .
Sultani AA; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia.
Hariyadi DM; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia.
Źródło:: Scientific reports [Sci Rep] 2022 Nov 12; Vol. 12 (1), pp. 19365. Date of Electronic Publication: 2022 Nov 12.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: London : Nature Publishing Group, copyright 2011-
MeSH Terms:: Drug Carriers*
Nanoparticles*
Rats ; Animals ; Lipids ; Rats, Wistar ; Skin ; Excipients ; Particle Size
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Substance Nomenclature:: 0 (Lipid Nanoparticles)
0 (Drug Carriers)
0 (Lipids)
0 (Excipients)
Entry Date(s):: Date Created: 20221113 Date Completed: 20221115 Latest Revision: 20230109
Update Code:: 20240105
PubMed Central ID:: PMC9653389
DOI:: 10.1038/s41598-022-23514-0
PMID:: 36371457
: Czasopismo naukowe

Pełny tekst

This study compared the ability of Nanostructured Lipid Carrier (NLC), Solid Lipid Nanoparticles (SLN), and Cream systems in delivering para Methoxycinnamic Acid (PMCA) to the dermis layer of the skin. Wistar rats were used as research subjects. NLC and SLN were made by applying the high shear homogenization method. Nile red was used as a penetration indicator based on its fluorescence. The interaction between fluorescence labeled NLC, SLN, or Cream and rat skin was visualized by fluorescence microscopy. Observations were made after 2 and 4.5 h of smearing the test sample. From the observations, it was known that the system/lipid base could penetrate the stratum corneum for delivering drugs. Penetration speed differs among systems as does the number of PMCAs that can be delivered. In this study, it can be concluded that the NLC system is able to deliver PMCA more quickly and in greater quantities to the dermis than SLN and Cream.
(© 2022. The Author(s).)

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