Colon-Targeted Layer-by-Layer Self-assembled Film: Pharmacokinetic Analysis of BCS Class I and Class III Model Drugs.

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Abstrakt

Tytuł:: Colon-Targeted Layer-by-Layer Self-assembled Film: Pharmacokinetic Analysis of BCS Class I and Class III Model Drugs.
Autorzy:: Janardhanam LSL; Department of Pharmacy, Birla Institute of Technology and Science (BITS) Pilani, Hyderabad Campus, Hyderabad, 500078, Telangana State, India.
Deokar AS; Department of Pharmacy, Birla Institute of Technology and Science (BITS) Pilani, Hyderabad Campus, Hyderabad, 500078, Telangana State, India.
Bollareddy SR; Department of Pharmacy, Birla Institute of Technology and Science (BITS) Pilani, Hyderabad Campus, Hyderabad, 500078, Telangana State, India.
Venuganti VVK; Department of Pharmacy, Birla Institute of Technology and Science (BITS) Pilani, Hyderabad Campus, Hyderabad, 500078, Telangana State, India. .
Źródło:: AAPS PharmSciTech [AAPS PharmSciTech] 2022 Nov 15; Vol. 23 (8), pp. 299. Date of Electronic Publication: 2022 Nov 15.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: New York : Springer
Original Publication: Arlington, VA : American Association of Pharmaceutical Scientists, c2000-
MeSH Terms:: Fluorouracil*
Colon*
Rats ; Animals ; Pharmaceutical Preparations ; Administration, Oral ; Polyelectrolytes
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Contributed Indexing:: Keywords: 5-fluorouracil; colon delivery; layer-by-layer assembled film; moxifloxacin HCl; pharmacokinetics
Substance Nomenclature:: 0 (Pharmaceutical Preparations)
U3P01618RT (Fluorouracil)
0 (Polyelectrolytes)
Entry Date(s):: Date Created: 20221115 Date Completed: 20221118 Latest Revision: 20221128
Update Code:: 20231215
DOI:: 10.1208/s12249-022-02450-2
PMID:: 36380249
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The aim of the study was to investigate the pharmacokinetic parameters of 5-fluorouracil (5FU) and moxifloxacin HCl (MF) after oral administration using layer-by-layer assembled film in enteric-coated capsule. The layer-by-layer (LbL) film was prepared by sequential layering of chitosan and sodium alginate polyelectrolytes containing either 5FU or MF. The films were in vitro evaluated for physical characteristics, drug loading and release behaviour. In vivo pharmacokinetic evaluation was performed in the rat model for three different drug concentrations after oral administration and compared with intravenous administration. The results showed that the thickness of 10-bilayer film was 147 ± 11.66 µm and 212.3 ± 7.19 µm after 5FU and MF loading, respectively. The LbL film with backing layer provided directional release of 5FU and MF, where 63.81 ± 4.52% and 101.38 ± 5.08%, respectively, was released in 24 h. 5FU showed non-linear pharmacokinetics compared with linear pharmacokinetics shown by MF after oral administration. There is a dose-dependent increase in C max after oral administration of 5FU and MF LbL film. The T max was found to be 720 min and 840 min for 5FU and MF after oral administration. The mean residence time and AUC 0-24 at 45 mg/kg were 871.4 ± 6.45 min and 198.6 ± 5.03 × 10 3 min per ng/mL and 1267 ± 142.4 min and 1590 ± 55.60 10 3 min per ng/mL for 5FU and MF, respectively. Taken together, colon-targeted LbL film can be developed for oral administration of drugs for local and systemic applications.
(© 2022. The Author(s), under exclusive licence to American Association of Pharmaceutical Scientists.)

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