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Tytuł:
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Stress induced aging in mouse eye.
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Autorzy:
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Xu Q; Department of Physiology and Biophysics, Center for Translational Vision Research, School of Medicine, University of California, Irvine, Irvine, California, USA.
Rydz C; Department of Physiology and Biophysics, Center for Translational Vision Research, School of Medicine, University of California, Irvine, Irvine, California, USA.
Nguyen Huu VA; Viterbi Family Department of Ophthalmology, Hamilton Glaucoma Center and Shiley Eye Institute, School of Medicine, University of California, San Diego, La Jolla, California, USA.
Rocha L; Viterbi Family Department of Ophthalmology, Hamilton Glaucoma Center and Shiley Eye Institute, School of Medicine, University of California, San Diego, La Jolla, California, USA.
Palomino La Torre C; Viterbi Family Department of Ophthalmology, Hamilton Glaucoma Center and Shiley Eye Institute, School of Medicine, University of California, San Diego, La Jolla, California, USA.
Lee I; Department of Physiology and Biophysics, Center for Translational Vision Research, School of Medicine, University of California, Irvine, Irvine, California, USA.
Cho W; Department of Physiology and Biophysics, Center for Translational Vision Research, School of Medicine, University of California, Irvine, Irvine, California, USA.
Jabari M; Viterbi Family Department of Ophthalmology, Hamilton Glaucoma Center and Shiley Eye Institute, School of Medicine, University of California, San Diego, La Jolla, California, USA.
Donello J; Department of Physiology and Biophysics, Center for Translational Vision Research, School of Medicine, University of California, Irvine, Irvine, California, USA.
Lyon DC; Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, Irvine, California, USA.
Brooke RT; Epigenetic Clock Development Foundation, Torrance, California, USA.
Horvath S; Epigenetic Clock Development Foundation, Torrance, California, USA.
Weinreb RN; Viterbi Family Department of Ophthalmology, Hamilton Glaucoma Center and Shiley Eye Institute, School of Medicine, University of California, San Diego, La Jolla, California, USA.
Ju WK; Viterbi Family Department of Ophthalmology, Hamilton Glaucoma Center and Shiley Eye Institute, School of Medicine, University of California, San Diego, La Jolla, California, USA.
Foik A; Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, Irvine, California, USA.; International Centre for Translational Eye Research, Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland.
Skowronska-Krawczyk D; Department of Physiology and Biophysics, Department of Ophthalmology, Center for Translational Vision Research, School of Medicine, University of California, Irvine, California, USA.
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Źródło:
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Aging cell [Aging Cell] 2022 Dec; Vol. 21 (12), pp. e13737. Date of Electronic Publication: 2022 Nov 17.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Oxford, UK : Wiley-Blackwell
Original Publication: Oxford, UK : Blackwell Pub., c2002-
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MeSH Terms:
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Intraocular Pressure*
Glaucoma*/genetics
Mice ; Animals ; Retinal Ganglion Cells ; Disease Models, Animal ; Aging/genetics ; Chromatin
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References:
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Grant Information:
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R01 EY027011 United States EY NEI NIH HHS; R01 EY031697 United States EY NEI NIH HHS; EY031697 United States EY NEI NIH HHS; EY027011 United States EY NEI NIH HHS
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Contributed Indexing:
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Keywords: IOP; aging; retinal ganglion cells; senescence; stress response
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Substance Nomenclature:
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0 (Chromatin)
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Entry Date(s):
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Date Created: 20221118 Date Completed: 20221216 Latest Revision: 20230701
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Update Code:
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20240104
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PubMed Central ID:
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PMC9741506
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DOI:
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10.1111/acel.13737
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PMID:
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36397653
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Aging, a universal process that affects all cells in an organism, is a major risk factor for a group of neuropathies called glaucoma, where elevated intraocular pressure is one of the known stresses affecting the tissue. Our understanding of molecular impact of aging on response to stress in retina is very limited; therefore, we developed a new mouse model to approach this question experimentally. Here we show that susceptibility to response to stress increases with age and is primed on chromatin level. We demonstrate that ocular hypertension activates a stress response that is similar to natural aging and involves activation of inflammation and senescence. We show that multiple instances of pressure elevation cause aging of young retina as measured on transcriptional and DNA methylation level and are accompanied by local histone modification changes. Our data show that repeated stress accelerates appearance of aging features in tissues and suggest chromatin modifications as the key molecular components of aging. Lastly, our work further emphasizes the importance of early diagnosis and prevention as well as age-specific management of age-related diseases, including glaucoma.
(© 2022 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.)
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