Rassf7a promotes spinal cord regeneration and controls spindle orientation in neural progenitor cells.

Szczegóły
Abstrakt

Tytuł:: Rassf7a promotes spinal cord regeneration and controls spindle orientation in neural progenitor cells.
Autorzy:: Zhu P; Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, China.; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China.; Sars-Fang Centre, Ministry of Education Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao, China.
Zheng P; Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, China.
Kong X; Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wang S; Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, China.
Cao M; Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhao C; Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, China.; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China.; Sars-Fang Centre, Ministry of Education Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao, China.
Źródło:: EMBO reports [EMBO Rep] 2023 Jan 09; Vol. 24 (1), pp. e54984. Date of Electronic Publication: 2022 Nov 21.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: 2014- : London, UK : Wiley Blackwell
Original Publication: Oxford, UK : Published for EMBO by Oxford University Press, 2000-
MeSH Terms:: Neural Stem Cells*/metabolism
Spinal Cord Regeneration*
Transcription Factors*
Zebrafish Proteins*/metabolism
Animals ; Axons/physiology ; Mammals ; Nerve Regeneration/physiology ; Neurogenesis ; Spinal Cord Injuries/genetics ; Spinal Cord Injuries/metabolism ; Zebrafish/growth & development ; Cell Cycle
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Contributed Indexing:: Keywords: Rassf7a; asymmetric neurogenic division; regeneration; spinal cord injury; spindle orientation
Molecular Sequence:: GEO GSE173350
Substance Nomenclature:: 0 (Transcription Factors)
0 (Zebrafish Proteins)
Entry Date(s):: Date Created: 20221121 Date Completed: 20230117 Latest Revision: 20231122
Update Code:: 20240104
PubMed Central ID:: PMC9827555
DOI:: 10.15252/embr.202254984
PMID:: 36408859
: Czasopismo naukowe

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Spinal cord injury (SCI) can cause long-lasting disability in mammals due to the lack of axonal regrowth together with the inability to reinitiate spinal neurogenesis at the injury site. Deciphering the mechanisms that regulate the proliferation and differentiation of neural progenitor cells is critical for understanding spinal neurogenesis after injury. Compared with mammals, zebrafish show a remarkable capability of spinal cord regeneration. Here, we show that Rassf7a, a member of the Ras-association domain family, promotes spinal cord regeneration after injury. Zebrafish larvae harboring a rassf7a mutation show spinal cord regeneration and spinal neurogenesis defects. Live imaging shows abnormal asymmetric neurogenic divisions and spindle orientation defects in mutant neural progenitor cells. In line with this, the expression of rassf7a is enriched in neural progenitor cells. Subcellular analysis shows that Rassf7a localizes to the centrosome and is essential for cell cycle progression. Our data indicate a role for Rassf7a in modulating spindle orientation and the proliferation of neural progenitor cells after spinal cord injury.
(© 2022 The Authors.)

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