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Tytuł:
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Akkermansia muciniphila ameliorates depressive disorders in a murine alcohol-LPS (mALPS) model.
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Autorzy:
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Guo D; Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, No. 1037 Luoyu road, Hongshan district, Wuhan, China. .
Park C; Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, No. 1037 Luoyu road, Hongshan district, Wuhan, China. .
Li Y; Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular-imaging, Center for Artificial Biology, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China.
Li B; Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, No. 1037 Luoyu road, Hongshan district, Wuhan, China. .
Yang Q; Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, No. 1037 Luoyu road, Hongshan district, Wuhan, China. .
Deng Y; Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, No. 1037 Luoyu road, Hongshan district, Wuhan, China. .
Gao NL; Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular-imaging, Center for Artificial Biology, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China.
Li R; Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, No. 1037 Luoyu road, Hongshan district, Wuhan, China. .
Wang X; Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, No. 1037 Luoyu road, Hongshan district, Wuhan, China. .
Yi L; Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, No. 1037 Luoyu road, Hongshan district, Wuhan, China. .
Liu Z; Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, No. 1037 Luoyu road, Hongshan district, Wuhan, China. .
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Źródło:
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Food & function [Food Funct] 2022 Dec 13; Vol. 13 (24), pp. 12766-12776. Date of Electronic Publication: 2022 Dec 13.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Cambridge : Royal Society of Chemistry
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MeSH Terms:
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Depressive Disorder*/chemically induced
Depressive Disorder*/therapy
Tumor Necrosis Factor-alpha*/genetics
Tumor Necrosis Factor-alpha*/metabolism
Akkermansia*
Probiotics*/therapeutic use
Complementary Therapies*/methods
Ethanol*/adverse effects
Animals ; Mice ; Dysbiosis/drug therapy ; Inflammation/drug therapy ; Inflammation/metabolism ; Lipopolysaccharides ; Serotonin
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Substance Nomenclature:
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0 (Lipopolysaccharides)
333DO1RDJY (Serotonin)
0 (Tumor Necrosis Factor-alpha)
3K9958V90M (Ethanol)
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SCR Organism:
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Akkermansia muciniphila
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Entry Date(s):
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Date Created: 20221123 Date Completed: 20221222 Latest Revision: 20221222
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Update Code:
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20240104
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DOI:
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10.1039/d2fo01478e
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PMID:
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36416490
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Depression is the most common mental disorder in the world. Recently, an increasing number of studies have reported alcohol-related depression. However, there is no simple, efficient, and time-saving alcohol-related depression animal model yet. Based on the fact that people with alcohol addiction often have impaired gastrointestinal (GI) tract health like dysbiosis, which serves as a primary factor to augment lipopolysaccharides (LPS), we first developed a murine alcohol-LPS model (mALPS), with oral gavage of LPS in acute alcohol treated mice, and successfully observed depression-like symptoms. We found that acute alcohol treatment damaged the intestinal barrier and caused dysbiosis, which further increased the translocation of LPS and neuroinflammatory responses (TNF-α and IL-1β) and led to abnormal expression of the depression-related genes, i.e. BDND and IDO , reduced the levels of 5-HT and caused depressive behaviors in mice. Probiotic intervention could improve depressive symptoms without notable adverse effects. Akkermansia muciniphila (AKK), one of the next-generation probiotics, has been widely used for the restoration of the intestinal barrier and reduction of inflammation. Here, we found that AKK significantly ameliorated alcohol-related depressive behaviors in a mALPS model, through enhancing the intestinal barrier and maintaining the homeostasis of the gut microbiota. Furthermore, AKK reduced serum LPS, ameliorated neuroinflammation (TNF-α and IL-1β), normalized the expression of depression-related genes and increased the 5-HT levels in the hippocampus. Our study suggests that AKK supplements will be a promising therapeutic regime for alcohol-associated depression in the future.