Major Adverse Cardiovascular Events in Korean Congenital Heart Disease Patients: A Nationwide Age- and Sex-Matched Case-Control Study.

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Tytuł:: Major Adverse Cardiovascular Events in Korean Congenital Heart Disease Patients: A Nationwide Age- and Sex-Matched Case-Control Study.
Autorzy:: Lee JS; Department of Pediatrics, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.
Jung JM; Department of Neurology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea.; \nKorea University Zebrafish Translational Medical Research Center, Ansan, Korea.
Choi J; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Seo WK; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. .
Shin HJ; Department of Thoracic and Cardiovascular Surgery, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea. .
Źródło:: Yonsei medical journal [Yonsei Med J] 2022 Dec; Vol. 63 (12), pp. 1069-1077.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Seoul : Yonsei University
MeSH Terms:: Heart Defects, Congenital*/complications
Heart Defects, Congenital*/epidemiology
Myocardial Infarction*
Stroke*
Humans ; Case-Control Studies ; Retrospective Studies ; Republic of Korea/epidemiology
References:: Eur Heart J. 2014 Mar;35(11):725-32. (PMID: 23882067)
Int J Epidemiol. 2019 Apr 1;48(2):455-463. (PMID: 30783674)
Heart. 2018 Apr;104(7):574-580. (PMID: 28847851)
J Am Coll Cardiol. 2011 Sep 27;58(14):1509-15. (PMID: 21939837)
Int J Cardiol. 2019 Jul 15;287:148-154. (PMID: 30712848)
Circulation. 2010 Nov 30;122(22):2264-72. (PMID: 21098444)
J Am Heart Assoc. 2018 Feb 8;7(4):. (PMID: 29437602)
Medicine (Baltimore). 2018 Jul;97(27):e11348. (PMID: 29979412)
Am Heart J. 2009 Nov;158(5):874-9. (PMID: 19853711)
Int J Cardiol. 2016 Sep 15;219:70-8. (PMID: 27288969)
Heart. 2008 Sep;94(9):1194-9. (PMID: 17646191)
Circulation. 2015 Dec 22;132(25):2385-94. (PMID: 26597113)
Am J Cardiol. 2017 Dec 15;120(12):2272-2277. (PMID: 29111211)
Cardiovasc Diagn Ther. 2021 Apr;11(2):563-576. (PMID: 33968634)
J Am Heart Assoc. 2021 Jul 6;10(13):e020939. (PMID: 34139861)
J Am Heart Assoc. 2019 May 21;8(10):e012030. (PMID: 31070503)
J Am Heart Assoc. 2019 Aug 6;8(15):e011870. (PMID: 31315496)
Heart. 2010 Aug;96(15):1223-6. (PMID: 20639238)
Epidemiology. 2017 Jul;28(4):608-618. (PMID: 28410350)
Korean Circ J. 2020 Aug;50(8):691-694. (PMID: 32725976)
Stroke Vasc Neurol. 2022 Apr;7(2):101-107. (PMID: 34702748)
J Am Coll Cardiol. 2011 Nov 15;58(21):2241-7. (PMID: 22078432)
Korean Circ J. 2020 Aug;50(8):677-690. (PMID: 32212426)
JAMA Cardiol. 2018 Sep 1;3(9):829-837. (PMID: 30027209)
Eur Heart J. 2021 Feb 11;42(6):563-645. (PMID: 32860028)
Cardiovasc J Afr. 2013 May;24(4):141-5. (PMID: 24217047)
BMC Cardiovasc Disord. 2014 Mar 21;14:38. (PMID: 24655794)
J Am Heart Assoc. 2020 Nov 17;9(22):e017704. (PMID: 33153356)
Korean Circ J. 2015 Sep;45(5):416-23. (PMID: 26413110)
Stroke. 2015 Feb;46(2):336-40. (PMID: 25516197)
Eur Heart J. 2021 Jul 8;42(26):2577-2586. (PMID: 33219678)
Grant Information:: 202003-01 Korea Korean Cardiac Research Foundation
Contributed Indexing:: Keywords: Congenital heart disease; Korean nationwide study; all-cause mortality; vascular events
Entry Date(s):: Date Created: 20221129 Date Completed: 20221130 Latest Revision: 20221224
Update Code:: 20240105
PubMed Central ID:: PMC9760894
DOI:: 10.3349/ymj.2022.0111
PMID:: 36444542
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Purpose: Congenital heart disease (CHD) is a known risk factor for acquired cardiovascular and cerebrovascular diseases. However, available evidence on CHD is limited mostly to Western populations. This study aimed to evaluate the prevalence of vascular events and all-cause mortality in Korean patients with CHD and to further corroborate CHD as a predictor of vascular events and all-cause mortality.
Materials and Methods: The claims data of the Korean National Health Insurance Service (NHIS) were retrospectively reviewed. Information regarding diagnostic codes, comorbidities, medical services, income level, and residential area was also collected. Outcomes of interest included stroke, myocardial infarction (MI), all-cause mortality, and major adverse cardiovascular events (MACE).
Results: We included 232203 patients with CHD and 3024633 individuals without CHD as a control group through age- and sex-matched 1:10 random sampling. The prevalences of hypertension, congestive heart failure, ischemic heart disease, hyperlipidemia, and atrial fibrillation were significantly higher in the CHD group, which had a more than two-fold higher incidence of vascular events and all-cause mortality, than in the group without CHD. Multivariable models demonstrated that CHD was a significant risk factor for stroke, MI, all-cause mortality, and MACE.
Conclusion: In conclusion, this nationwide study demonstrates that Korean patients with CHD have a high incidence of comorbidities, vascular events, and mortality. CHD has been established as an important predictor of cardiovascular events. Further studies are warranted to identify high-risk patients with CHD and related factors to prevent vascular events.
Competing Interests: The authors have no potential conflicts of interest to disclose.
(© Copyright: Yonsei University College of Medicine 2022.)

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