Fluoroquinolone resistance in bacterial isolates from ocular infections: Trend in antibiotic susceptibility patterns between 2005-2020.

Tytuł:: Fluoroquinolone resistance in bacterial isolates from ocular infections: Trend in antibiotic susceptibility patterns between 2005-2020.
Autorzy:: Chatterjee S; Cornea and Anterior Segment Services, MGM Eye Institute, Raipur, Chhattisgarh, India.
Agrawal D; Cornea and Anterior Segment Services, MGM Eye Institute, Raipur, Chhattisgarh, India.
Gomase SN; Cornea and Anterior Segment Services, MGM Eye Institute, Raipur, Chhattisgarh, India.
Parchand SM; Vitreo-Retina Services, MGM Eye Institute, Raipur, Chhattisgarh, India.
Gangwe AB; Vitreo-Retina Services, MGM Eye Institute, Raipur, Chhattisgarh, India.
Mishra M; Oculoplasty and Ocular Oncology Services, MGM Eye Institute, Raipur, Chhattisgarh, India.
Źródło:: Indian journal of ophthalmology [Indian J Ophthalmol] 2022 Dec; Vol. 70 (12), pp. 4391-4398.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: Mumbai : Medknow Publications
Original Publication: Bombay : All-India Ophthalmological Society
MeSH Terms:: Fluoroquinolones*/pharmacology
Eye Infections*
Humans ; Moxifloxacin ; Gatifloxacin ; Cefuroxime ; Colistin ; Longitudinal Studies ; Retrospective Studies ; Ciprofloxacin ; Ofloxacin ; Anti-Bacterial Agents/pharmacology
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Contributed Indexing:: Keywords: Antibiotic resistance; bacteria; endophthalmitis; fluoroquinolone; keratitis
Substance Nomenclature:: 0 (Fluoroquinolones)
U188XYD42P (Moxifloxacin)
L4618BD7KJ (Gatifloxacin)
O1R9FJ93ED (Cefuroxime)
Z67X93HJG1 (Colistin)
5E8K9I0O4U (Ciprofloxacin)
A4P49JAZ9H (Ofloxacin)
0 (Anti-Bacterial Agents)
Entry Date(s):: Date Created: 20221201 Date Completed: 20221202 Latest Revision: 20230222
Update Code:: 20240105
PubMed Central ID:: PMC9940527
DOI:: 10.4103/ijo.IJO_1033_22
PMID:: 36453351
: Czasopismo naukowe

Pełny tekst

Purpose: To assess the fluoroquinolone resistance pattern and trends among bacterial isolates from ocular infections over a 16-year period and explore alternative antibiotics in fluoroquinolone-resistant strains.
Methods: In this retrospective, longitudinal study, the microbiology laboratory records of patients with different ocular infections diagnosed at an eye institute in central India from 2005-2020 were reviewed to determine the pattern of fluoroquinolone (ciprofloxacin, ofloxacin, gatifloxacin, and moxifloxacin) resistance. Antibiotic susceptibility testing was done using the Kirby-Bauer disc diffusion method.
Results: In 725 Gram-positive bacteria, the resistance of ciprofloxacin, ofloxacin, gatifloxacin, and moxifloxacin was 55.9% (95% confidence interval [CI]: 52.2 - 59.6), 42.7% (95% CI: 39.0 - 46.4), 47.6% (95% CI: 43.9 - 51.3), and 45.6% (95% CI: 41.7-49.5), respectively. In 266 Gram-negative bacteria, the resistance of ciprofloxacin, ofloxacin, gatifloxacin, and moxifloxacin was 57.9% (95% CI: 51.9 - 63.9), 56.0% (95% CI: 49.7 - 62.1), 59.9% (95% CI: 53.8 - 66.0), and 74.3% (95% CI: 68.3 - 80.2), respectively. A declining trend in resistance to ciprofloxacin (P < 0.001), ofloxacin (P < 0.001), and moxifloxacin (P < 0.001) was seen in Gram-positive bacteria, whereas a reduction in resistance to only moxifloxacin (P = 0.04) was seen in Gram-negative bacteria. In fluoroquinolone-resistant Gram-positive bacteria, cefuroxime exhibited the highest susceptibility, whereas in fluoroquinolone-resistant Gram-negative bacteria, colistin exhibited the highest susceptibility.
Conclusion: Fluoroquinolone resistance was high among bacteria from ocular infections in central India, but a declining trend in resistance to some of the fluoroquinolones was observed in recent times. Cefuroxime and colistin emerged as alternatives in fluoroquinolone-resistant Gram-positive and Gram-negative bacterial infections, respectively.
Competing Interests: None

Comment in: Indian J Ophthalmol. 2022 Dec;70(12):4399. (PMID: 36453352)

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